Methotrimeprazine

59 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Nasal Spray Metoclopramide Injection Metronidazole Diazepam Rectal Midazolam Injection Metronidazole Topical
2 Contraindicated 55 Major 2 Moderate
All (59) Contraindicated (2) Major (55) Moderate (2)

Contraindicated

Methotrimeprazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Methotrimeprazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Methotrimeprazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Methotrimeprazine Sertraline Explained An increased risk of QT interval prolongation Details Methotrimeprazine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Methotrimeprazine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Methotrimeprazine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Methotrimeprazine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Methotrimeprazine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Methotrimeprazine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Methotrimeprazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Methotrimeprazine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Methotrimeprazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Methotrimeprazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Methotrimeprazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Methotrimeprazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Methotrimeprazine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Methotrimeprazine Dasatinib Phyrago An increased risk of QT interval prolongation Details Methotrimeprazine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Methotrimeprazine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Methotrimeprazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Methotrimeprazine Diazepam Rectal Diastat Increased risk of CNS depression Details Methotrimeprazine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Methotrimeprazine Encorafenib Braftovi Increased risk of QT interval prolongation Details Methotrimeprazine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Methotrimeprazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Methotrimeprazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Methotrimeprazine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Methotrimeprazine Fostemsavir Rukobia Increased risk of torsade de pointes Details Methotrimeprazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Methotrimeprazine Glasdegib Daurismo Increased risk of QT interval prolongation Details Methotrimeprazine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Methotrimeprazine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Methotrimeprazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Methotrimeprazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Methotrimeprazine Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Methotrimeprazine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Methotrimeprazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Methotrimeprazine Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Methotrimeprazine Lacosamide Injection Motpoly An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.