Methyclothiazide

51 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Ibuprofen Diclofenac Ophthalmic Diclofenac Topical (Actinic Keratosis) Digoxin Naproxen
35 Major 16 Moderate
All (51) Major (35) Moderate (16)

Moderate

Methyclothiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Methyclothiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Methyclothiazide Benazepril Lotensin Reduction of blood pressure Details Methyclothiazide Calcitriol Rocaltrol Increased serum calcium levels resulting in hypercalcemia Details Methyclothiazide Calcitriol Topical Vectical Increased serum calcium levels resulting in hypercalcemia Details Methyclothiazide Captopril Capoten® Reduction of blood pressure Details Methyclothiazide Cyclophosphamide Cytoxan® Increased risk of myelosuppression Details Methyclothiazide Cyclophosphamide Injection Cytoxan® Injection Increased risk of myelosuppression Details Methyclothiazide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Methyclothiazide Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Methyclothiazide Enalapril Epaned Reduction of blood pressure Details Methyclothiazide Fosinopril Monopril® Reduction of blood pressure Details Methyclothiazide Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Methyclothiazide Moexipril Univasc® Reduction of blood pressure Details Methyclothiazide Olodaterol Oral Inhalation Striverdi An increased risk of ECG changes and/or an increased risk of hypokalemia Details Methyclothiazide Perindopril Aceon Reduction of blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.