Methyclothiazide

51 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Ibuprofen Diclofenac Ophthalmic Diclofenac Topical (Actinic Keratosis) Digoxin Naproxen

35 Major 16 Moderate

All (51) Major (35) Moderate (16)

Major

Methyclothiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Methyclothiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Methyclothiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Methyclothiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Methyclothiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Methyclothiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Methyclothiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Methyclothiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Methyclothiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Methyclothiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Methyclothiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Lithium Carbonate Lithobid Lithium toxicity Details Methyclothiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Methyclothiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Methyclothiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Methyclothiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Methyclothiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Methyclothiazide Benazepril Lotensin Reduction of blood pressure Details Methyclothiazide Calcitriol Rocaltrol Increased serum calcium levels resulting in hypercalcemia Details Methyclothiazide Calcitriol Topical Vectical Increased serum calcium levels resulting in hypercalcemia Details

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