Methylphenidate Transdermal Patch

67 interactions 302 cited references

Also sold as: Daytrana Daytrana®

About Methylphenidate Transdermal Patch

Methylphenidate transdermal patches are used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age). Methylphenidate is in a class of medications called cent… Read the full Methylphenidate Transdermal Patch drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Phenelzine Ozanimod Methylene Blue Linezolid Isocarboxazid

11 Contraindicated 54 Major 2 Moderate

All (67) Contraindicated (11) Major (54) Moderate (2)

Contraindicated

Methylphenidate Transdermal Patch Isocarboxazid Marplan An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Linezolid Zyvox An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Methylene Blue Provayblue An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Ozanimod An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Phenelzine Nardil An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Pimozide An increased risk of motor and phonic tics Details Methylphenidate Transdermal Patch Procarbazine An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Rasagiline Azilect An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Safinamide Xadago An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Selegiline Anipryl An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Transdermal Patch Tranylcypromine Parnate An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details

Major

Methylphenidate Transdermal Patch Acenocoumarol Increased coumarin anticoagulants exposure and an increased risk of bleeding Details Methylphenidate Transdermal Patch Amifampridine Increased risk of seizures Details Methylphenidate Transdermal Patch Amphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Methylphenidate Transdermal Patch Bupropion Aplenzin Increased risk of seizures Details Methylphenidate Transdermal Patch Cimetidine Tagamet Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Transdermal Patch Citalopram Celexa Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Transdermal Patch Clomipramine Anafranil Increased clomiPRAMINE exposure, an increased risk of seizures and an increased risk of drug-drug interactions Details Methylphenidate Transdermal Patch Desflurane Suprane Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Transdermal Patch Desipramine Norpramin Increased desipramine exposure Details Methylphenidate Transdermal Patch Dexlansoprazole Dexilant Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Transdermal Patch Dextroamphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Methylphenidate Transdermal Patch Donepezil Adlarity Reduced seizure threshold Details Methylphenidate Transdermal Patch Ebrotidine Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Transdermal Patch Enflurane Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Transdermal Patch Escitalopram Lexapro Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Transdermal Patch Esomeprazole Nexium Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Transdermal Patch Famotidine Calmicid Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Transdermal Patch Fluoxetine RECONCILE Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Transdermal Patch Fluvoxamine Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Transdermal Patch Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Methylphenidate Transdermal Patch Halothane Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Transdermal Patch Hydroxychloroquine Plaquenil An increased risk of seizures Details Methylphenidate Transdermal Patch Imipramine Increased imipramine exposure Details Methylphenidate Transdermal Patch Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Methylphenidate Transdermal Patch Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Methylphenidate Transdermal Patch Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Methylphenidate Transdermal Patch Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Methylphenidate Transdermal Patch Iobenguane I 131 Azedra Inaccurate dosimetry calculations or reduced efficacy Details Methylphenidate Transdermal Patch Ioflupane I 123 Interference with ioflupane I 123 imaging Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.