Methylprednisolone

Name: Methylprednisolone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

58 interactions 3 explained in plain English

Also sold as: Depo-Medrol HybriSil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Meloxicam Diclofenac Topical (Actinic Keratosis) Levofloxacin Diclofenac Ophthalmic Ibuprofen

1 Contraindicated 48 Major 9 Moderate

All (58) Contraindicated (1) Major (48) Moderate (9)

Major

Methylprednisolone Moxifloxacin Injection Avelox An increased risk of tendon rupture Details Methylprednisolone Moxifloxacin Ophthalmic Moxeza® An increased risk of tendon rupture Details Methylprednisolone Nabumetone Relafen Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Naproxen Aleve Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Nifedipine Adalat® Reduced NIFEdipine exposure Details Methylprednisolone Ofloxacin Floxin® An increased risk of tendon rupture Details Methylprednisolone Ofloxacin Ophthalmic Ocuflox An increased risk of tendon rupture Details Methylprednisolone Ofloxacin Otic Floxin® Otic An increased risk of tendon rupture Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.