Methylprednisolone
58 interactions 3 explained in plain English
Also sold as:
Depo-Medrol
HybriSil
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Desmopressin Nasal
Meloxicam
Diclofenac Topical (Actinic Keratosis)
Levofloxacin
Diclofenac Ophthalmic
Ibuprofen
Moderate
Methylprednisolone Apixaban Eliquis Explained Increased risk of gastrointestinal bleeding Details Methylprednisolone Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Methylprednisolone Dabigatran Pradaxa® Increased risk of gastrointestinal bleeding Details Methylprednisolone Dabigatran Etexilate Increased risk of gastrointestinal bleeding Details Methylprednisolone Edoxaban Savaysa Increased risk of gastrointestinal bleeding Details Methylprednisolone Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Methylprednisolone Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Methylprednisolone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Methylprednisolone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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