Methylprednisolone
58 interactions 3 explained in plain English
Also sold as:
Depo-Medrol
HybriSil
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Desmopressin Nasal
Meloxicam
Diclofenac Topical (Actinic Keratosis)
Levofloxacin
Diclofenac Ophthalmic
Ibuprofen
Contraindicated
Methylprednisolone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia DetailsMajor
Methylprednisolone Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Methylprednisolone Aldesleukin Proleukin Reduced antitumor effectiveness Details Methylprednisolone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Methylprednisolone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Methylprednisolone Atogepant Qulipta Reduced atogepant exposure Details Methylprednisolone Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Methylprednisolone Amlodipine Amvaz® Reduced amLODIPine exposure Details Methylprednisolone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Methylprednisolone Bromfenac Ophthalmic Bromday® Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Cyclosporine Injection Atopica Increased cycloSPORINE exposure, increased cycloSPORINE toxicity and steroid excess Details Methylprednisolone Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure, increased cycloSPORINE toxicity and steroid excess Details Methylprednisolone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Etodolac Lodine Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Fenoprofen Fenopron Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Methylprednisolone Flurbiprofen Ansaid Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Flurbiprofen Ophthalmic Ocufen Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Methylprednisolone Gemifloxacin Factive An increased risk of tendon rupture Details Methylprednisolone Ibuprofen Addaprin Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Ketoconazole Topical Extina® Foam An increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electrolyte disturbances, hypertension, hy... Details Methylprednisolone Ketoprofen Actron® Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Ketorolac Acular Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Ketorolac Injection Acular Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Ketorolac Nasal Spray Sprix Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Ketorolac Ophthalmic Acular Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Methylprednisolone Levofloxacin Levaquin An increased risk of tendon rupture Details Methylprednisolone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Methylprednisolone Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Methylprednisolone Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Methylprednisolone Lumateperone Caplyta Reduced lumateperone exposure Details Methylprednisolone Meclofenamate Meclodium® Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Mefenamic Acid Ponstel® Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Meloxicam Alloxate Increased risk of gastrointestinal ulcer or bleeding Details Methylprednisolone Meloxicam Injection Alloxate Increased risk of gastrointestinal ulcer or bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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