Drug Interaction Report

Metoclopramide Injection and Paregoric: Interaction Details

A pharmacist-reviewed analysis of the Metoclopramide Injection and Paregoric interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Paregoric

No brand names on record
+

Metoclopramide Injection

Gimoti Metozolv Pileran Reglan Reglan® I.V.
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 247 documented Metoclopramide Injection interactions, 174 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased risk of CNS depression

Interaction Deep Dive

Concomitant use of metoclopramide and a CNS depressant (eg, sedatives, hypnotics, opiates, and anxiolytics) may result in an increased risk of CNS depression and should be avoided. If coadministration is necessary, monitor for adverse effects1.

Why it happens (mechanism)

Additive pharmacologic effect

Common questions

Can I take Metoclopramide Injection and Paregoric together?

Increased risk of CNS depression Always confirm with your pharmacist or prescriber before making any change.

How serious is the Metoclopramide Injection and Paregoric interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Metoclopramide Injection or Paregoric need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (1)

  1. Product Information: REGLAN(R) oral tablets, metoclopramide oral tablets. ANI Pharmaceuticals, Inc. (per FDA), Baudette, MN, 2017. DailyMed
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Paregoric

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All Paregoric interactions (29)
Also serious with: Morphine Injection Diazepam Nasal Spray Palonosetron Injection Midazolam Nasal Spray
Metoclopramide Injection

Keep reading about Metoclopramide Injection

All Metoclopramide Injection interactions (247) Metoclopramide Injection drug information
Also serious with: Fluvoxamine Haloperidol Iloperidone Imipramine

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