Paregoric

29 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Paregoric Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Sertraline Explained An increased risk of serotonin syndrome Details Paregoric Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Paregoric Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paregoric Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paregoric Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Paregoric Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Paregoric Clopidogrel Plavix Reduced efficacy of clopidogrel Details Paregoric Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Paregoric Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Paregoric Esketamine Nasal Spray Spravato Increased risk of sedation Details Paregoric Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Paregoric Granisetron Injection Granisol Increased risk of serotonin syndrome Details Paregoric Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Lacosamide Injection Motpoly An increased risk of CNS depression Details Paregoric Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Paregoric Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Paregoric Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Paregoric Metoclopramide Injection Gimoti Increased risk of CNS depression Details Paregoric Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Paregoric Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Paregoric Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Paregoric Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paregoric Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.