Paregoric
29 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Lacosamide Injection
Midazolam Nasal Spray
Buprenorphine
Diazepam Nasal Spray
Granisetron Injection
Palonosetron Injection
Major
Paregoric Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Sertraline Explained An increased risk of serotonin syndrome Details Paregoric Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Paregoric Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paregoric Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paregoric Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Paregoric Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Paregoric Clopidogrel Plavix Reduced efficacy of clopidogrel Details Paregoric Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Paregoric Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Paregoric Esketamine Nasal Spray Spravato Increased risk of sedation Details Paregoric Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Paregoric Granisetron Injection Granisol Increased risk of serotonin syndrome Details Paregoric Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Lacosamide Injection Motpoly An increased risk of CNS depression Details Paregoric Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Paregoric Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Paregoric Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Paregoric Metoclopramide Injection Gimoti Increased risk of CNS depression Details Paregoric Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Paregoric Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Paregoric Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Paregoric Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Paregoric Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Paregoric Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsModerate
Paregoric Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Paregoric Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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