Metoclopramide Nasal Spray

247 interactions 689 cited references

Also sold as: Gimoti Gimoti®

About Metoclopramide Nasal Spray

Metoclopramide nasal spray is used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by… Read the full Metoclopramide Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iloperidone Imipramine Levomilnacipran Loxapine Zuclopenthixol Mavorixafor

63 Contraindicated 174 Major 6 Moderate 4 Minor

All (247) Contraindicated (63) Major (174) Moderate (6) Minor (4)

Contraindicated

Metoclopramide Nasal Spray Perphenazine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Pimavanserin Nuplazid An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Pimozide An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Prochlorperazine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Promazine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Protriptyline An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Quetiapine Seroquel An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Risperidone Perseris An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Sertindole An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Sertraline Increased risk of metoclopramide exposure and an increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Sibutramine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Sulpiride An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Thioridazine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Thiothixene An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Tianeptine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Trifluoperazine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Triflupromazine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Trimipramine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Venlafaxine An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Vilazodone Viibryd An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Vortioxetine Trintellix An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Ziprasidone Geodon An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Metoclopramide Nasal Spray Zuclopenthixol An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Metoclopramide Nasal Spray Acepromazine PROMACE Increased risk of CNS depression Details Metoclopramide Nasal Spray Alfentanil Increased risk of CNS depression Details Metoclopramide Nasal Spray Alprazolam Xanax Increased risk of CNS depression Details Metoclopramide Nasal Spray Amantadine Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Amobarbital Amytal Increased risk of CNS depression Details Metoclopramide Nasal Spray Anileridine Increased risk of CNS depression Details Metoclopramide Nasal Spray Apomorphine Apokyn Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Articaine An increased risk of methemoglobinemia Details Metoclopramide Nasal Spray Baclofen Fleqsuvy Increased risk of CNS depression Details Metoclopramide Nasal Spray Benperidol Increased risk of CNS depression Details Metoclopramide Nasal Spray Benzhydrocodone Increased risk of CNS depression Details Metoclopramide Nasal Spray Benztropine Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Biperiden Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Bromazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Bromocriptine Cycloset Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Buprenorphine Belbuca Increased risk of CNS depression Details Metoclopramide Nasal Spray Bupropion Aplenzin Increased metoclopramide exposure and risk of increased adverse events Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.