Metoclopramide Nasal Spray

247 interactions 689 cited references
Also sold as: Gimoti Gimoti®
About Metoclopramide Nasal Spray

Metoclopramide nasal spray is used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by… Read the full Metoclopramide Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iloperidone Imipramine Levomilnacipran Loxapine Zuclopenthixol Mavorixafor
63 Contraindicated 174 Major 6 Moderate 4 Minor
All (247) Contraindicated (63) Major (174) Moderate (6) Minor (4)

Major

Metoclopramide Nasal Spray Acepromazine PROMACE Increased risk of CNS depression Details Metoclopramide Nasal Spray Alfentanil Increased risk of CNS depression Details Metoclopramide Nasal Spray Alprazolam Xanax Increased risk of CNS depression Details Metoclopramide Nasal Spray Amantadine Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Amobarbital Amytal Increased risk of CNS depression Details Metoclopramide Nasal Spray Anileridine Increased risk of CNS depression Details Metoclopramide Nasal Spray Apomorphine Apokyn Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Articaine An increased risk of methemoglobinemia Details Metoclopramide Nasal Spray Baclofen Fleqsuvy Increased risk of CNS depression Details Metoclopramide Nasal Spray Benperidol Increased risk of CNS depression Details Metoclopramide Nasal Spray Benzhydrocodone Increased risk of CNS depression Details Metoclopramide Nasal Spray Benztropine Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Biperiden Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Bromazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Bromocriptine Cycloset Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Buprenorphine Belbuca Increased risk of CNS depression Details Metoclopramide Nasal Spray Bupropion Aplenzin Increased metoclopramide exposure and risk of increased adverse events Details Metoclopramide Nasal Spray Buspirone Bucapsol Increased risk of CNS depression Details Metoclopramide Nasal Spray Butabarbital Increased risk of CNS depression Details Metoclopramide Nasal Spray Butorphanol Butorphic Increased risk of CNS depression Details Metoclopramide Nasal Spray Cabergoline Dostinex® Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Metoclopramide Nasal Spray Carbidopa Lodosyn Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Carbinoxamine Carbzah Increased risk of CNS depression Details Metoclopramide Nasal Spray Carisoprodol Soma Increased risk of CNS depression Details Metoclopramide Nasal Spray Carphenazine Increased risk of CNS depression Details Metoclopramide Nasal Spray Chloral Hydrate Increased risk of CNS depression Details Metoclopramide Nasal Spray Chlordiazepoxide Increased risk of CNS depression Details Metoclopramide Nasal Spray Chlorzoxazone Lorzone Increased risk of CNS depression Details Metoclopramide Nasal Spray Clobazam Onfi Increased risk of CNS depression Details Metoclopramide Nasal Spray Clonazepam Klonopin Increased risk of CNS depression Details Metoclopramide Nasal Spray Clorazepate Tranxene Increased risk of CNS depression Details Metoclopramide Nasal Spray Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of CNS depression Details Metoclopramide Nasal Spray Cyclobenzaprine Amrix Increased risk of CNS depression Details Metoclopramide Nasal Spray Cyclosporine Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Metoclopramide Nasal Spray Dexmedetomidine Dexased Increased risk of CNS depression Details Metoclopramide Nasal Spray Diacetylmorphine Increased risk of CNS depression Details Metoclopramide Nasal Spray Diazepam Diastat Increased risk of CNS depression Details Metoclopramide Nasal Spray Dichloralphenazone Increased risk of CNS depression Details Metoclopramide Nasal Spray Difenoxin Increased risk of CNS depression Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.