Metoclopramide Nasal Spray

247 interactions 689 cited references

Also sold as: Gimoti Gimoti®

About Metoclopramide Nasal Spray

Metoclopramide nasal spray is used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by… Read the full Metoclopramide Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iloperidone Imipramine Levomilnacipran Loxapine Zuclopenthixol Mavorixafor

63 Contraindicated 174 Major 6 Moderate 4 Minor

All (247) Contraindicated (63) Major (174) Moderate (6) Minor (4)

Major

Metoclopramide Nasal Spray Digoxin Cardoxin® Reduced digoxin exposure Details Metoclopramide Nasal Spray Dihydrocodeine Increased risk of CNS depression Details Metoclopramide Nasal Spray Diphenhydramine Banophen Increased risk of CNS depression Details Metoclopramide Nasal Spray Diphenoxylate Increased risk of CNS depression Details Metoclopramide Nasal Spray Doxylamine Aldex AN Increased risk of CNS depression Details Metoclopramide Nasal Spray Droperidol Increased risk of CNS depression Details Metoclopramide Nasal Spray Enflurane Increased risk of CNS depression Details Metoclopramide Nasal Spray Entacapone Comtan Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Estazolam Increased risk of CNS depression Details Metoclopramide Nasal Spray Eszopiclone Lunesta Increased risk of CNS depression Details Metoclopramide Nasal Spray Ethchlorvynol Increased risk of CNS depression Details Metoclopramide Nasal Spray Ethopropazine Increased risk of CNS depression Details Metoclopramide Nasal Spray Ethylmorphine Increased risk of CNS depression Details Metoclopramide Nasal Spray Fentanyl Increased risk of CNS depression Details Metoclopramide Nasal Spray Flibanserin Addyi Increased risk of CNS depression Details Metoclopramide Nasal Spray Fluoxetine RECONCILE Increased metoclopramide exposure and risk of increased adverse events Details Metoclopramide Nasal Spray Flurazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Fluspirilene Increased risk of CNS depression Details Metoclopramide Nasal Spray Fospropofol Increased risk of CNS depression Details Metoclopramide Nasal Spray Furazolidone Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Halazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Halothane Increased risk of CNS depression Details Metoclopramide Nasal Spray Hexobarbital Increased risk of CNS depression Details Metoclopramide Nasal Spray Hydrocodone Hysingla Increased risk of CNS depression Details Metoclopramide Nasal Spray Hydromorphone Dilaudid Increased risk of CNS depression Details Metoclopramide Nasal Spray Hydroxyzine Increased risk of CNS depression Details Metoclopramide Nasal Spray Insulin Afrezza Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Aspart, Recombinant Fiasp Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Bovine Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Degludec Tresiba Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Detemir Levemir Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Glargine, Recombinant Basaglar Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Glulisine Apidra Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Lispro, Recombinant Admelog Risk of hyperglycemia Details Metoclopramide Nasal Spray Iproniazid Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Isocarboxazid Marplan Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Isoflurane Fluriso Increased risk of CNS depression Details Metoclopramide Nasal Spray Ketamine Increased risk of CNS depression Details Metoclopramide Nasal Spray Ketazolam Increased risk of CNS depression Details Metoclopramide Nasal Spray Ketobemidone Increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.