Metoclopramide Nasal Spray

247 interactions 689 cited references
Also sold as: Gimoti Gimoti®
About Metoclopramide Nasal Spray

Metoclopramide nasal spray is used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by… Read the full Metoclopramide Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iloperidone Imipramine Levomilnacipran Loxapine Zuclopenthixol Mavorixafor
63 Contraindicated 174 Major 6 Moderate 4 Minor
All (247) Contraindicated (63) Major (174) Moderate (6) Minor (4)

Major

Metoclopramide Nasal Spray Levodopa Inbrija Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Levorphanol Xyvona Increased risk of CNS depression Details Metoclopramide Nasal Spray Lidocaine Akten An increased risk of methemoglobinemia Details Metoclopramide Nasal Spray Linezolid Zyvox Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Lorazepam Ativan Increased risk of CNS depression Details Metoclopramide Nasal Spray Lumefantrine Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details Metoclopramide Nasal Spray Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Metoclopramide Nasal Spray Meclizine Antivert Increased risk of CNS depression Details Metoclopramide Nasal Spray Melperone Increased risk of CNS depression Details Metoclopramide Nasal Spray Mephobarbital Increased risk of CNS depression Details Metoclopramide Nasal Spray Meprobamate Increased risk of CNS depression Details Metoclopramide Nasal Spray Meptazinol Increased risk of CNS depression Details Metoclopramide Nasal Spray Metaxalone Skelaxin Increased risk of CNS depression Details Metoclopramide Nasal Spray Methadone Diskets Increased risk of CNS depression Details Metoclopramide Nasal Spray Methdilazine Increased risk of CNS depression Details Metoclopramide Nasal Spray Methocarbamol Atmeksi Increased risk of CNS depression Details Metoclopramide Nasal Spray Methohexital Brevital Increased risk of CNS depression Details Metoclopramide Nasal Spray Methylene Blue Provayblue Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Midazolam Increased risk of CNS depression Details Metoclopramide Nasal Spray Moclobemide Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Moricizine Increased risk of CNS depression Details Metoclopramide Nasal Spray Morphine Increased risk of CNS depression Details Metoclopramide Nasal Spray Morphine Sulfate Liposome Increased risk of CNS depression Details Metoclopramide Nasal Spray Nalbuphine Increased risk of CNS depression Details Metoclopramide Nasal Spray Nialamide Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Nicomorphine Increased risk of CNS depression Details Metoclopramide Nasal Spray Nitrazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Nitrous Oxide Increased risk of CNS depression Details Metoclopramide Nasal Spray Opicapone Ongentys Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Opium Increased risk of CNS depression Details Metoclopramide Nasal Spray Opium Alkaloids Increased risk of CNS depression Details Metoclopramide Nasal Spray Orphenadrine Increased risk of CNS depression Details Metoclopramide Nasal Spray Oxazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Oxycodone Oxaydo Increased risk of CNS depression Details Metoclopramide Nasal Spray Oxymorphone Increased risk of CNS depression Details Metoclopramide Nasal Spray Papaveretum Increased risk of CNS depression Details Metoclopramide Nasal Spray Paregoric Increased risk of CNS depression Details Metoclopramide Nasal Spray Paroxetine Paxil Increased metoclopramide exposure and risk of increased adverse events Details Metoclopramide Nasal Spray Pentazocine Increased risk of CNS depression Details Metoclopramide Nasal Spray Pentobarbital Fatal-Plus Increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.