Metoclopramide Nasal Spray

247 interactions 689 cited references

Also sold as: Gimoti Gimoti®

About Metoclopramide Nasal Spray

Metoclopramide nasal spray is used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by… Read the full Metoclopramide Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iloperidone Imipramine Levomilnacipran Loxapine Zuclopenthixol Mavorixafor

63 Contraindicated 174 Major 6 Moderate 4 Minor

All (247) Contraindicated (63) Major (174) Moderate (6) Minor (4)

Major

Metoclopramide Nasal Spray Fluspirilene Increased risk of CNS depression Details Metoclopramide Nasal Spray Fospropofol Increased risk of CNS depression Details Metoclopramide Nasal Spray Furazolidone Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Halazepam Increased risk of CNS depression Details Metoclopramide Nasal Spray Halothane Increased risk of CNS depression Details Metoclopramide Nasal Spray Hexobarbital Increased risk of CNS depression Details Metoclopramide Nasal Spray Hydrocodone Hysingla Increased risk of CNS depression Details Metoclopramide Nasal Spray Hydromorphone Dilaudid Increased risk of CNS depression Details Metoclopramide Nasal Spray Hydroxyzine Increased risk of CNS depression Details Metoclopramide Nasal Spray Insulin Afrezza Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Aspart, Recombinant Fiasp Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Bovine Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Degludec Tresiba Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Detemir Levemir Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Glargine, Recombinant Basaglar Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Glulisine Apidra Risk of hyperglycemia Details Metoclopramide Nasal Spray Insulin Lispro, Recombinant Admelog Risk of hyperglycemia Details Metoclopramide Nasal Spray Iproniazid Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Isocarboxazid Marplan Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Isoflurane Fluriso Increased risk of CNS depression Details Metoclopramide Nasal Spray Ketamine Increased risk of CNS depression Details Metoclopramide Nasal Spray Ketazolam Increased risk of CNS depression Details Metoclopramide Nasal Spray Ketobemidone Increased risk of CNS depression Details Metoclopramide Nasal Spray Levodopa Inbrija Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Levorphanol Xyvona Increased risk of CNS depression Details Metoclopramide Nasal Spray Lidocaine Akten An increased risk of methemoglobinemia Details Metoclopramide Nasal Spray Linezolid Zyvox Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Lorazepam Ativan Increased risk of CNS depression Details Metoclopramide Nasal Spray Lumefantrine Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details Metoclopramide Nasal Spray Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Metoclopramide Nasal Spray Meclizine Antivert Increased risk of CNS depression Details Metoclopramide Nasal Spray Melperone Increased risk of CNS depression Details Metoclopramide Nasal Spray Mephobarbital Increased risk of CNS depression Details Metoclopramide Nasal Spray Meprobamate Increased risk of CNS depression Details Metoclopramide Nasal Spray Meptazinol Increased risk of CNS depression Details Metoclopramide Nasal Spray Metaxalone Skelaxin Increased risk of CNS depression Details Metoclopramide Nasal Spray Methadone Diskets Increased risk of CNS depression Details Metoclopramide Nasal Spray Methdilazine Increased risk of CNS depression Details Metoclopramide Nasal Spray Methocarbamol Atmeksi Increased risk of CNS depression Details Metoclopramide Nasal Spray Methohexital Brevital Increased risk of CNS depression Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.