Metoclopramide and Atovaquone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Metoclopramide
No brand names on recordAtovaquone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduction of atovaquone bioavailability
Interaction Deep Dive
Metoclopramide may reduce the bioavailability of atovaquone and should be used only if other antiemetics are not available. Concomitant treatment with metoclopramide has been associated with a 50% reduction in steady-state atovaquone plasma concentrations1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) Concomitant treatment with metoclopramide has been associated with a 50% reduction in steady-state atovaquone plasma concentrations 1.
Common questions
Can I take Metoclopramide and Atovaquone together?
Reduction of atovaquone bioavailability Always confirm with your pharmacist or prescriber before making any change.
How serious is the Metoclopramide and Atovaquone interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Metoclopramide or Atovaquone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: MEPRON oral suspension, atovaquone oral suspension. GlaxoSmithKline (per FDA), Research Triangle Park, NC, 2019. DailyMed
Keep reading about Metoclopramide
Keep reading about Atovaquone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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