Miconazole Topical

37 interactions 192 cited references
Also sold as: Aloe Vesta Antifungal Critic-Aid Clear DermaFungal Dermagran Desenex® Fungoid® Tincture Lotrimin® AF Athlete's Foot Powder Lotrimin® AF Athlete's Foot Spray Deodorant Powder Lotrimin® AF Athlete's Foot Spray Liquid Lotrimin® AF Athlete's Foot Spray Powder Lotrimin® AF Jock Itch Spray Powder Micatin® Cream Monistat-Derm® Tetterine Ting® Antifungal Spray Powder Triple Paste AF Vusion® Ointment (as a combination product containing Miconazole, Zinc Oxide) Zeasorb®-AF Powder
About Miconazole Topical

Topical miconazole is used to treat tinea corporis(ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes… Read the full Miconazole Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Deuruxolitinib Pimozide Amiodarone Carvedilol Celecoxib Cilostazol
2 Contraindicated 22 Major 13 Moderate
All (37) Contraindicated (2) Major (22) Moderate (13)

Contraindicated

Miconazole Topical Deuruxolitinib Increased deuruxolitinib exposure and an increased risk of deuruxolitinib-related adverse effects such as thrombosis Details Miconazole Topical Pimozide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Major

Miconazole Topical Amiodarone Nexterone Increased amiodarone exposure Details Miconazole Topical Carvedilol Coreg Increased carvedilol concentrations and an increased risk of bradycardia or heart block Details Miconazole Topical Celecoxib Celebrex Increased celecoxib exposure Details Miconazole Topical Cilostazol Pletal® Increased cilostazol exposure Details Miconazole Topical Domperidone Increased domperidone exposure and an increased risk of QT interval prolongation Details Miconazole Topical Erdafitinib Balversa Increased erdafitinib exposure Details Miconazole Topical Escitalopram Lexapro Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Miconazole Topical Etonogestrel Nexplanon Increased etonogestrel exposure Details Miconazole Topical Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Miconazole Topical Glimepiride Amaryl Severe hypoglycemia Details Miconazole Topical Ifosfamide Ifex Decreased ifosfamide effectiveness Details Miconazole Topical Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Miconazole Topical Methadone Diskets Increased methadone exposure and an increased risk of opioid adverse effects Details Miconazole Topical Naloxegol Movantik Increased naloxegol exposure Details Miconazole Topical Olaparib Lynparza Increased olaparib exposure Details Miconazole Topical Phenobarbital Fidoquel Increased PHENobarbital exposure and an increased risk of PHENobarbital-related adverse effects Details Miconazole Topical Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Miconazole Topical Piperaquine Increased exposure of piperaquine Details Miconazole Topical Primidone Mysoline Increased PHENobarbital exposure and an increased risk of PHENobarbital-related adverse effects Details Miconazole Topical Simeprevir Olysio® Increased simeprevir exposure Details Miconazole Topical Voriconazole Vfend Increased voriconazole exposure Details Miconazole Topical Warfarin Coumadin Increased warfarin exposure, an increased INR and an increased risk of bleeding Details

Moderate

Miconazole Topical Aceclofenac Increased exposure of diclofenac Details Miconazole Topical Acenocoumarol An increased risk of bleeding Details Miconazole Topical Anisindione Increased risk of bleeding Details Miconazole Topical Cyclosporine Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Miconazole Topical Diclofenac Aleve Arthritis Pain Increased exposure of diclofenac Details Miconazole Topical Dicumarol An increased risk of bleeding Details Miconazole Topical Ethinyl Estradiol Increased exposure to ethinyl estradiol Details Miconazole Topical Nateglinide Starlix® Increased risk of hypoglycemia Details Miconazole Topical Oxybutynin Ditropan Increased oxybutynin exposure or plasma concentrations Details Miconazole Topical Phenindione An increased risk of bleeding Details Miconazole Topical Phenprocoumon Increased risk of bleeding Details Miconazole Topical Tolterodine Detrol Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Miconazole Topical Trimetrexate Increased trimetrexate toxicity (bone marrow suppression, renal & hepatic dysfunction, and gastrointestinal ulceration) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.