Midazolam

Contraindicated

Midazolam Ketoconazole Topical Extina® Foam Increased midazolam exposure and potentially increased midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details

Major

Midazolam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Midazolam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Midazolam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Midazolam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Midazolam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Midazolam Calcifediol Rayaldee Altered serum levels of calcifediol Details Midazolam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Midazolam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Midazolam Diazepam Nasal Spray Valtoco Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Diazepam Rectal Diastat Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Diphenhydramine Injection Banophen Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Esketamine Nasal Spray Spravato Increased risk of sedation Details Midazolam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Midazolam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Midazolam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Midazolam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Midazolam Lacosamide Injection Motpoly An increased risk of CNS depression Details Midazolam Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Midazolam Lenacapavir Injection Sunlenca Increased midazolam exposure Details Midazolam Lenacapavir Oral Sunlenca Increased midazolam exposure Details Midazolam Letermovir Injection Prevymis Increased midazolam exposure and increased risk for prolonged sedation Details Midazolam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Midazolam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Midazolam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Midazolam Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Midazolam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Midazolam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Midazolam Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Midazolam Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Midazolam Omeprazole Gastrobim Explained Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Midazolam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Midazolam Cyclosporine Injection Atopica Decreased midazolam clearance and increased midazolam plasma concentrations Details Midazolam Cyclosporine Ophthalmic Cequa Decreased midazolam clearance and increased midazolam plasma concentrations Details Midazolam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

Minor

Midazolam Atorvastatin Atorvaliq Prolonged midazolam efficacy Details