Midazolam

Name: Midazolam Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

39 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Orlistat Levodopa Oral Inhalation Aripiprazole Injection Diazepam Rectal Nalbuphine Injection

1 Contraindicated 31 Major 6 Moderate 1 Minor

All (39) Contraindicated (1) Major (31) Moderate (6) Minor (1)

Moderate

Midazolam Omeprazole Gastrobim Explained Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Midazolam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Midazolam Cyclosporine Injection Atopica Decreased midazolam clearance and increased midazolam plasma concentrations Details Midazolam Cyclosporine Ophthalmic Cequa Decreased midazolam clearance and increased midazolam plasma concentrations Details Midazolam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.