Milk Thistle
9 interactions 1 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Milk Thistle Relugolix Orgovyx Explained Increased relugolix exposure Details Milk Thistle Digoxin Cardoxin® Increased digoxin exposure Details Milk Thistle Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Milk Thistle Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Milk Thistle Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance DetailsModerate
Milk Thistle Metronidazole Flagyl Reduced metronidazole and active metabolite exposure Details Milk Thistle Metronidazole Injection Flagyl Reduced metronidazole and active metabolite exposure Details Milk Thistle Metronidazole Topical MetroCream® Reduced metronidazole and active metabolite exposure Details Milk Thistle Metronidazole Vaginal MetroGel® Vaginal Reduced metronidazole and active metabolite exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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