Mobocertinib

Name: Mobocertinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

105 interactions 10 explained in plain English

Also sold as: Exkivity

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Lefamulin Medroxyprogesterone Clindamycin Topical Metronidazole Topical Oxaliplatin Injection

2 Contraindicated 100 Major 3 Moderate

All (105) Contraindicated (2) Major (100) Moderate (3)

Contraindicated

Mobocertinib Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Mobocertinib Lefamulin Xenleta Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.