Montelukast

Name: Montelukast Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

18 interactions 188 cited references

Also sold as: Singulair Singulair®

About Montelukast

Montelukast is a leukotriene receptor antagonist used to prevent asthma symptoms and treat allergic rhinitis. Read the full Montelukast drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Teriflunomide Omaveloxolone Phenobarbital Pixantrone Olanzapine Vorasidenib

14 Major 3 Moderate 1 Minor

All (18) Major (14) Moderate (3) Minor (1)

Moderate

Montelukast Gemfibrozil Lopid Elevated montelukast plasma concentrations Details Montelukast Prednisone Deltasone Severe peripheral edema Details Montelukast Trimethoprim Primsol Increased exposure of CYP2C8 substrates Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.