Nalbuphine Injection

257 interactions 271 cited references
Also sold as: Nubain®
About Nalbuphine Injection

Nalbuphine injection is used to relieve moderate to severe pain. It is also used with other medications and anesthetic agents before, during, and after surgery and other medical procedures. Nalbuphine injection is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses… Read the full Nalbuphine Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Phenelzine Safinamide Samidorphan Tranylcypromine Isocarboxazid
6 Contraindicated 244 Major 7 Moderate
All (257) Contraindicated (6) Major (244) Moderate (7)

Contraindicated

Nalbuphine Injection Isocarboxazid Marplan An increased risk of CNS depression Details Nalbuphine Injection Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Nalbuphine Injection Phenelzine Nardil An increased risk of serotonin syndrome Details Nalbuphine Injection Safinamide Xadago Increased risk of serotonin syndrome Details Nalbuphine Injection Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Nalbuphine Injection Tranylcypromine Parnate An increased risk of serotonin syndrome and an increased risk of CNS depression Details

Major

Nalbuphine Injection Acepromazine PROMACE Increased risk of respiratory and CNS depression Details Nalbuphine Injection Alfentanil An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Nalbuphine Injection Almotriptan Increased risk of serotonin syndrome Details Nalbuphine Injection Alprazolam Xanax Increased risk of respiratory and CNS depression Details Nalbuphine Injection Amifampridine Increased risk of seizures Details Nalbuphine Injection Amineptine Increased risk of serotonin syndrome Details Nalbuphine Injection Amitriptyline Elavil Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Nalbuphine Injection Amobarbital Amytal Increased risk of respiratory and CNS depression Details Nalbuphine Injection Amoxapine Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Nalbuphine Injection Amphetamine Dexedrine An increased risk of serotonin syndrome Details Nalbuphine Injection Aripiprazole Abilify Increased risk of respiratory and CNS depression Details Nalbuphine Injection Asenapine Saphris Increased risk of respiratory and CNS depression Details Nalbuphine Injection Baclofen Fleqsuvy Increased risk of respiratory and CNS depression Details Nalbuphine Injection Benperidol Increased risk of respiratory and CNS depression Details Nalbuphine Injection Benzhydrocodone Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Nalbuphine Injection Benzphetamine An increased risk of serotonin syndrome Details Nalbuphine Injection Bromazepam Increased risk of respiratory and CNS depression Details Nalbuphine Injection Bromopride Potentiation of sedative effects Details Nalbuphine Injection Brompheniramine Respa-BR Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Nalbuphine Injection Buprenorphine Belbuca Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Nalbuphine Injection Bupropion Aplenzin Increased risk of seizures Details Nalbuphine Injection Buspirone Bucapsol Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Nalbuphine Injection Butabarbital Increased risk of respiratory and CNS depression Details Nalbuphine Injection Butalbital An increased risk of CNS depression Details Nalbuphine Injection Butorphanol Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Nalbuphine Injection Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Nalbuphine Injection Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Nalbuphine Injection Cannabis An increased risk of CNS depression Details Nalbuphine Injection Carbamazepine Carbatrol Increased risk of serotonin syndrome and an increased risk of CNS depression Details Nalbuphine Injection Carbidopa Lodosyn An increased risk of CNS depression Details Nalbuphine Injection Carbinoxamine Carbzah An increased risk of CNS depression Details Nalbuphine Injection Carphenazine Increased risk of respiratory and CNS depression Details Nalbuphine Injection Cetirizine Aller-Tec Increased risk of CNS depression Details Nalbuphine Injection Chloral Hydrate Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.