Nateglinide

209 interactions 492 cited references

Also sold as: Starlix®

About Nateglinide

Nateglinide is used alone or in combination with other medications to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) in people whose diabetes cannot be controlled by diet and exercise alone. Nateglinide belongs to a class o… Read the full Nateglinide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Abiraterone Acetate Insulin Glulisine (Rdna Origin) Injection Chloroquine Ofloxacin Otic Letermovir Injection

1 Contraindicated 95 Major 112 Moderate 1 Minor

All (209) Contraindicated (1) Major (95) Moderate (112) Minor (1)

Moderate

Nateglinide Darunavir Altered glycemic control Details Nateglinide Enalaprilat An increased risk of hypoglycemia Details Nateglinide Eucalyptus Increased risk of hypoglycemia Details Nateglinide Exenatide Bydureon Increased risk of hypoglycemia Details Nateglinide Fluconazole Diflucan Increased risk of hypoglycemia Details Nateglinide Fosamprenavir Lexiva Worsening glycemic control Details Nateglinide Fosphenytoin Cerebyx Reduced hypoglycemic action of nateglinide Details Nateglinide Glecaprevir Altered glycemic control resulting in severe symptomatic hypoglycemia Details Nateglinide Glucomannan Increased risk of hypoglycemia Details Nateglinide Guanethidine Increased risk of hypoglycemia Details Nateglinide Guar Gum Increased risk of hypoglycemia Details Nateglinide Gymnema Sylvestre Increased risk of hypoglycemia Details Nateglinide Indinavir Worsening glycemic control Details Nateglinide Isocarboxazid Marplan An increased risk of hypoglycemia Details Nateglinide Kratom Increased CYP3A substrate exposure Details Nateglinide Levobunolol Betagan Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Linezolid Zyvox An increased risk of hypoglycemia Details Nateglinide Liraglutide Saxenda An increased risk of hypoglycemia Details Nateglinide Lopinavir Worsening glycemic control Details Nateglinide Mavacamten Camzyos Reduced nateglinide exposure and reduced efficacy of nateglinide Details Nateglinide Methylene Blue Provayblue An increased risk of hypoglycemia Details Nateglinide Metipranolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Metoprolol Kapspargo Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Metreleptin Increased risk of hypoglycemia Details Nateglinide Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Nelfinavir Viracept Worsening glycemic control Details Nateglinide Oxandrolone Oxandrin Increased risk of hypoglycemia Details Nateglinide Oxprenolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Ozanimod An increased risk of hypoglycemia Details Nateglinide Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Perindopril Aceon An increased risk of hypoglycemia Details Nateglinide Phenelzine Nardil An increased risk of hypoglycemia Details Nateglinide Phenytoin Dilantin Reduced hypoglycemic action of nateglinide Details Nateglinide Pibrentasvir Altered glycemic control resulting in severe symptomatic hypoglycemia Details Nateglinide Pindolol Visken® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Pioglitazone Actos Increased risk of hypoglycemia Details Nateglinide Practolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Procarbazine An increased risk of hypoglycemia Details Nateglinide Propranolol Hemangeol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Psyllium Alramucil® Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.