Nateglinide and Darunavir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Darunavir
No brand names on recordNateglinide
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered glycemic control
Interaction Deep Dive
Hyperglycemia has been reported with use of protease inhibitors, and concomitant use with antidiabetic agents may lead to worsening glycemic control. However, darunavir is a CYP3A inhibitor that can increase exposure to CYP3A substrates1, such as nateglinide 2. If coadministration is required, dose adjustment of the antidiabetic drug may be required, and close monitoring 1 of glucose control and for hypoglycemia or other adverse reactions of nateglinide is recommended.
Why it happens (mechanism)
Protease inhibitor-induced hyperglycemia or inhibition of CYP3A-mediated metabolism of nateglinide
Common questions
Can I take Nateglinide and Darunavir together?
Altered glycemic control Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nateglinide and Darunavir interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Nateglinide or Darunavir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: PREZCOBIX(TM) oral tablets, darunavir cobicistat oral tablets. Janssen Pharmaceuticals, Inc. (per manufacturer), Titusville, NJ, 2015. DailyMed
- Product Information: Starlix(R) oral tablets, nateglinide oral tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2011. DailyMed
Keep reading about Darunavir
Keep reading about Nateglinide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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