Darunavir and Lurasidone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Darunavir
No brand names on recordLurasidone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased lurasidone exposure, an increased risk of darunavir exposure and an increased risk of lurasidone/darunavir-related adverse effects
Interaction Deep Dive
Concurrent use of darunavir and lurasidone is contraindicated as it may increase lurasidone exposure, which may have potential for serious or life-threatening reactions. A reduction in the dose of lurasidone may be needed when coadministered. Coadministration of darunavir (CYP3A substrate) and lurasidone (CYP3A inhibitor) may also increase darunavir exposure12.
Why it happens (mechanism)
Inhibition of CYP3A-mediated metabolism of lurasidone; inhibition of CYP3A-mediated metabolism of darunavir
Common questions
Can I take Darunavir and Lurasidone together?
Increased lurasidone exposure, an increased risk of darunavir exposure and an increased risk of lurasidone/darunavir-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Darunavir and Lurasidone interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Darunavir or Lurasidone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: PREZCOBIX® PED oral tablets for suspension, darunavir cobicistat oral tablets for suspension. Janssen Products, LP (per FDA), Horsham, PA, 2026. DailyMed
- Product Information: PREZCOBIX® oral tablets, darunavir cobicistat oral tablets. Janssen Products, LP (per FDA), Horsham, PA, 2026. DailyMed
Keep reading about Darunavir
Keep reading about Lurasidone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist