Lurasidone

135 interactions 1 explained in plain English 395 cited references
Also sold as: Latuda Latuda®
About Lurasidone

Lurasidone is an atypical antipsychotic used to treat schizophrenia and depression in bipolar disorder. Read the full Lurasidone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Lurasidone Ketoconazole Topical Extina® Foam Increased lurasidone exposure Details Lurasidone Apalutamide Erleada Reduced lurasidone exposure Details Lurasidone Atazanavir Reyataz Increased lurasidone exposure Details Lurasidone Boceprevir Increased lurasidone exposure Details Lurasidone Bromopride Increased risk of extrapyramidal reactions Details Lurasidone Carbamazepine Carbatrol Reduced lurasidone exposure Details Lurasidone Ceritinib Zykadia Increased lurasidone exposure Details Lurasidone Clarithromycin Biaxin Increased lurasidone exposure Details Lurasidone Cobicistat Tybost Increased lurasidone exposure and an increased cobicistat exposure Details Lurasidone Conivaptan Vaprisol Increased lurasidone exposure Details Lurasidone Darunavir Increased lurasidone exposure, an increased risk of darunavir exposure and an increased risk of lurasidone/darunavir-related adver... Details Lurasidone Ensitrelvir Increased lurasidone exposure and an increased risk of lurasidone-related adverse events Details Lurasidone Enzalutamide Xtandi Reduced lurasidone exposure Details Lurasidone Fosphenytoin Cerebyx Reduced lurasidone exposure Details Lurasidone Idelalisib Zydelig Increased lurasidone exposure Details Lurasidone Indinavir Increased lurasidone exposure Details Lurasidone Itraconazole Sporanox Increased lurasidone exposure Details Lurasidone Ivosidenib Tibsovo Reduced lurasidone exposure Details Lurasidone Ketoconazole Extina Increased lurasidone exposure Details Lurasidone Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Lurasidone Lonafarnib Zokinvy Increased lurasidone exposure Details Lurasidone Lumacaftor Reduced lurasidone exposure Details Lurasidone Metoclopramide An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Lurasidone Mibefradil Increased lurasidone exposure Details Lurasidone Mifepristone Korlym Increased lurasidone exposure Details Lurasidone Mitotane Lysodren Reduced lurasidone exposure Details Lurasidone Nefazodone Increased lurasidone exposure Details Lurasidone Nelfinavir Viracept Increased lurasidone exposure Details Lurasidone Nirmatrelvir Serious and/or life-threatening reactions such as cardiac arrhythmias Details Lurasidone Paritaprevir Increased lurasidone exposure Details Lurasidone Phenytoin Dilantin Reduced lurasidone exposure Details Lurasidone Posaconazole Noxafil Increased lurasidone exposure and risk of increased adverse events Details Lurasidone Ribociclib Kisqali Increased lurasidone exposure Details Lurasidone Rifampin Rifadin Reduced lurasidone exposure Details Lurasidone Rifapentine Priftin Reduced lurasidone exposure Details Lurasidone Ritonavir Norvir Increased lurasidone exposure Details Lurasidone Saquinavir Increased lurasidone exposure Details Lurasidone St John's Wort Reduced lurasidone exposure Details Lurasidone Telaprevir Increased lurasidone exposure Details Lurasidone Telithromycin Increased lurasidone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.