Lurasidone and Apalutamide: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Apalutamide
Lurasidone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced lurasidone exposure
Interaction Deep Dive
Concomitant use of lurasidone (a CYP3A4 substrate) and a strong CYP3A4 inducer is contraindicated as coadministration may result in reduced lurasidone exposure. Coadministration of a single dose of lurasidone 40 mg with rifAMPin 600 mg/day at steady state (for 8 days) resulted in a decrease in lurasidone Cmax and AUC to one-seventh and one-fifth of the levels relative to lurasidone administration alone, respectively1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of lurasidone
Literature reports
1 report — tap to read
a) Coadministration of a single dose of lurasidone 40 mg with rifAMPin 600 mg/day at steady state (for 8 days) resulted in a decrease in lurasidone Cmax and AUC to one-seventh and one-fifth of the levels relative to lurasidone administration alone, respectively 1.
Common questions
Can I take Lurasidone and Apalutamide together?
Reduced lurasidone exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lurasidone and Apalutamide interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Lurasidone or Apalutamide need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LATUDA(R) oral tablets, lurasidone HCl oral tablets. Sunovion Pharmaceuticals Inc (per FDA), Marlborough, MA, 2019. DailyMed
Keep reading about Apalutamide
Keep reading about Lurasidone
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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