Darunavir

Contraindicated

Darunavir Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Darunavir Simvastatin Flolipid Explained Increased simvastatin exposure; increased risk of myopathy or rhabdomyolysis Details Darunavir Alfuzosin UroXatral Increased alfuzosin exposure, thereby increasing the risk for serious and/or life-threatening reactions Details Darunavir Dihydroergotamine Injection DHE-45® Injection An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Darunavir Dihydroergotamine Nasal Spray Migranal An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Darunavir Ivabradine Corlanor Increased ivabradine exposure Details Darunavir Lovastatin Altocor® Increased lovastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Darunavir Lurasidone Latuda Increased lurasidone exposure, an increased risk of darunavir exposure and an increased risk of lurasidone/darunavir-related adver... Details Darunavir Maraviroc Selzentry Increased maraviroc exposure Details Darunavir Methylergonovine Methergine An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Darunavir Midazolam Nasal Spray Nayzilam Increased midazolam exposure and an increased risk of prolonged sedation or respiratory depression Details Darunavir Midazolam Injection Nayzilam Increased midazolam exposure and an increased risk of prolonged sedation or respiratory depression Details Darunavir Naloxegol Movantik Increased naloxegol exposure Details

Major

Darunavir Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Darunavir Omeprazole Gastrobim Explained Altered (reduced/increased) omeprazole exposure, an increased darunavir-related adverse reactions and reduced efficacy of omeprazo... Details Darunavir Amitriptyline Elavil Explained Increased tricyclic antidepressant/CYP2D6 substrate exposure Details Darunavir Sertraline Explained Increased selective serotonin reuptake inhibitor (SSRI) exposure and an increased risk of SSRI-related adverse reactions Details Darunavir Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Darunavir Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Darunavir Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of ARIPiprazole-related adverse effects Details Darunavir Atenolol Tenormin Explained Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Darunavir Azathioprine Azasan An increased risk of hepatotoxicity Details Darunavir Acebutolol Sectral® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Atorvastatin Atorvaliq Increased atorvastatin exposure, an increased darunavir exposure and an increased risk of myopathy or rhabdomyolysis Details Darunavir Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Darunavir Amlodipine Amvaz® Increased amLODIPine exposure, an increased darunavir exposure and an increased risk of amLODIPine/darunavir-related adverse effec... Details Darunavir Avanafil Stendra Increased avanafil exposure and an increased risk of avanafil-related adverse reactions Details Darunavir Bedaquiline Sirturo Increased bedaquiline exposure Details Darunavir Betaxolol Betoptic S Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Betaxolol Ophthalmic Betoptic® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Bisoprolol Zebeta® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Bosutinib Bosulif Increased bosutinib exposure Details Darunavir Brexpiprazole Rexulti Increased brexpiprazole exposure Details Darunavir Budesonide Entocort Increased corticosteroid exposure Details Darunavir Budesonide Nasal Spray Rhinocort Increased corticosteroid exposure Details Darunavir Budesonide Oral Inhalation Pulmicort Increased corticosteroid exposure Details Darunavir Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Darunavir Ciclesonide Nasal Spray Omnaris Increased corticosteroid exposure Details Darunavir Ciclesonide Oral Inhalation Alvesco Increased corticosteroid exposure Details