Darunavir

115 interactions 11 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Darunavir Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Darunavir Omeprazole Gastrobim Explained Altered (reduced/increased) omeprazole exposure, an increased darunavir-related adverse reactions and reduced efficacy of omeprazo... Details Darunavir Amitriptyline Elavil Explained Increased tricyclic antidepressant/CYP2D6 substrate exposure Details Darunavir Sertraline Explained Increased selective serotonin reuptake inhibitor (SSRI) exposure and an increased risk of SSRI-related adverse reactions Details Darunavir Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Darunavir Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Darunavir Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of ARIPiprazole-related adverse effects Details Darunavir Atenolol Tenormin Explained Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Darunavir Azathioprine Azasan An increased risk of hepatotoxicity Details Darunavir Acebutolol Sectral® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Atorvastatin Atorvaliq Increased atorvastatin exposure, an increased darunavir exposure and an increased risk of myopathy or rhabdomyolysis Details Darunavir Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Darunavir Amlodipine Amvaz® Increased amLODIPine exposure, an increased darunavir exposure and an increased risk of amLODIPine/darunavir-related adverse effec... Details Darunavir Avanafil Stendra Increased avanafil exposure and an increased risk of avanafil-related adverse reactions Details Darunavir Bedaquiline Sirturo Increased bedaquiline exposure Details Darunavir Betaxolol Betoptic S Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Betaxolol Ophthalmic Betoptic® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Bisoprolol Zebeta® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Bosutinib Bosulif Increased bosutinib exposure Details Darunavir Brexpiprazole Rexulti Increased brexpiprazole exposure Details Darunavir Budesonide Entocort Increased corticosteroid exposure Details Darunavir Budesonide Nasal Spray Rhinocort Increased corticosteroid exposure Details Darunavir Budesonide Oral Inhalation Pulmicort Increased corticosteroid exposure Details Darunavir Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Darunavir Ciclesonide Nasal Spray Omnaris Increased corticosteroid exposure Details Darunavir Ciclesonide Oral Inhalation Alvesco Increased corticosteroid exposure Details Darunavir Clopidogrel Plavix Reduced clopidogrel active metabolite exposure Details Darunavir Cyclophosphamide Cytoxan® Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Darunavir Cyclophosphamide Injection Cytoxan® Injection Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Darunavir Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased darunavir exposure Details Darunavir Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased darunavir exposure Details Darunavir Dasatinib Phyrago Increased dasatinib exposure and an increased risk of dasatinib-related adverse effects Details Darunavir Dexamethasone Injection Decadron Reduced darunavir exposure, reduced efficacy of darunavir and an increased dexAMETHasone exposure Details Darunavir Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced darunavir exposure, reduced efficacy of darunavir and an increased dexAMETHasone exposure Details Darunavir Diazepam Nasal Spray Valtoco Increased sedatives exposure and an increased risk of prolonged sedation or respiratory depression Details Darunavir Diazepam Rectal Diastat Increased sedatives exposure and an increased risk of prolonged sedation or respiratory depression Details Darunavir Didanosine Videx® Increased adverse effects Details Darunavir Digoxin Cardoxin® Increased digoxin exposure Details Darunavir Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.