Darunavir and Aripiprazole Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Darunavir
No brand names on recordAripiprazole Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased ARIPiprazole exposure and an increased risk of ARIPiprazole-related adverse effects
Interaction Deep Dive
Concomitant use of darunavir with ARIPiprazole (an antipsychotic and a dual CYP3A4 and CYP2D6 substrate) may increase the exposure of ARIPiprazole. A decrease in the dose of antipsychotic that is metabolized by CYP3A or CYP2D6 may be needed when coadministered with darunavir/ritonavir1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of ARIPiprazole; inhibition of CYP2D6-mediated metabolism of ARIPiprazole
Common questions
Can I take Darunavir and Aripiprazole Injection together?
Increased ARIPiprazole exposure and an increased risk of ARIPiprazole-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Darunavir and Aripiprazole Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Darunavir or Aripiprazole Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: PREZISTA(R) oral suspension, oral tablets, darunavir oral suspension, oral tablets. Janssen Products, LP (per FDA), Horsham, PA, 2023. DailyMed
Keep reading about Darunavir
Keep reading about Aripiprazole Injection
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