Nelfinavir

171 interactions 12 explained in plain English
Also sold as: Viracept
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lovastatin Midazolam Injection Lurasidone Dihydroergotamine Injection Colchicine Finerenone
15 Contraindicated 143 Major 13 Moderate
All (171) Contraindicated (15) Major (143) Moderate (13)

Contraindicated

Nelfinavir Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Nelfinavir Simvastatin Flolipid Explained An increased risk of myopathy or rhabdomyolysis Details Nelfinavir Alfuzosin UroXatral Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Nelfinavir Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Nelfinavir Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Nelfinavir Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Nelfinavir Ivabradine Corlanor Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Nelfinavir Ketoconazole Topical Extina® Foam Increased ketoconazole exposure, an increased nelfinavir exposure and an increased risk of QT interval prolongation Details Nelfinavir Lovastatin Altocor® Increased lovastatin exposure and an increased risk of lovastatin-related adverse effects, such as, risk of myopathy or rhabdomyol... Details Nelfinavir Lurasidone Latuda Increased lurasidone exposure Details Nelfinavir Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Nelfinavir Midazolam Nasal Spray Nayzilam Increased midazolam exposure and an increase risk of prolonged sedation or respiratory depression Details Nelfinavir Midazolam Injection Nayzilam Increased midazolam exposure and an increase risk of prolonged sedation or respiratory depression Details Nelfinavir Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Nelfinavir Nimodipine Nimotop Increased serum nimodipine concentrations Details

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