Niacin

24 interactions 109 cited references
Also sold as: Endur-Acin Endur-Amide Niacor Niacor® Niaspan Niaspan® Nicolar® Slo-Niacin Slo-Niacin®
About Niacin

Niacin is a B-complex vitamin used to lower cholesterol and triglycerides and prevent niacin deficiency. Read the full Niacin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cerivastatin Insulin Icodec-Abae Rosuvastatin Pitavastatin Levoketoconazole Insulin Aspart, Recombinant
14 Major 6 Moderate 4 Minor
All (24) Major (14) Moderate (6) Minor (4)

Major

Niacin Simvastatin Flolipid Increased niacin and simvastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Niacin Azathioprine Azasan An increased risk of hepatotoxicity Details Niacin Atorvastatin Atorvaliq Increased atorvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Niacin Lovastatin Altocor® Increased risk of myopathy or rhabdomyolysis Details Niacin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Niacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Niacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Niacin Cerivastatin An increased risk of myopathy or rhabdomyolysis Details Niacin Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Niacin Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Niacin Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Niacin Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Niacin Pitavastatin Livalo Increased risk of myopathy and rhabdomyolysis Details Niacin Rosuvastatin Crestor An increased risk of myopathy or rhabdomyolysis Details

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