Nicomorphine
29 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Midazolam Injection
Nalbuphine Injection
Levodopa Oral Inhalation
Palonosetron Injection
Diazepam Rectal
Cetirizine Injection
Major
Nicomorphine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Nicomorphine Sertraline Explained An increased risk of serotonin syndrome Details Nicomorphine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Nicomorphine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Nicomorphine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Nicomorphine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Nicomorphine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Nicomorphine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Nicomorphine Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Nicomorphine Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Nicomorphine Esketamine Nasal Spray Spravato Increased risk of sedation Details Nicomorphine Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Nicomorphine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Nicomorphine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Nicomorphine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Nicomorphine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Nicomorphine Lacosamide Injection Motpoly An increased risk of CNS depression Details Nicomorphine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Nicomorphine Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Nicomorphine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Nicomorphine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Nicomorphine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Nicomorphine Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Nicomorphine Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Nicomorphine Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Nicomorphine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Nicomorphine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsModerate
Nicomorphine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Nicomorphine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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