Nitroglycerin Sublingual

15 interactions 500 cited references
Also sold as: Nitrostat Nitrostat®
About Nitroglycerin Sublingual

Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring. Nitroglyc… Read the full Nitroglycerin Sublingual drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Avanafil Riociguat Sildenafil Tadalafil Vardenafil Alteplase, Recombinant
5 Contraindicated 4 Major 6 Moderate
All (15) Contraindicated (5) Major (4) Moderate (6)

Contraindicated

Nitroglycerin Sublingual Avanafil Stendra Potentiation of hypotensive effects Details Nitroglycerin Sublingual Riociguat Adempas Increased risk of hypotension Details Nitroglycerin Sublingual Sildenafil Liqrev Potentiation of hypotensive effects Details Nitroglycerin Sublingual Tadalafil Adcirca Increased hypotensive effects of nitrates Details Nitroglycerin Sublingual Vardenafil Levitra Potentiation of hypotensive effects Details

Major

Nitroglycerin Sublingual Alteplase, Recombinant Activase Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Nitroglycerin Sublingual Articaine An increased risk of methemoglobinemia Details Nitroglycerin Sublingual Heparin A decrease in partial thromboplastin time Details Nitroglycerin Sublingual Lidocaine Akten An increased risk of methemoglobinemia Details

Moderate

Nitroglycerin Sublingual Acetylcysteine Acetadote Enhanced hypotension and nitroglycerin-induced headache Details Nitroglycerin Sublingual Apomorphine Apokyn An increased risk of hypotension Details Nitroglycerin Sublingual Aspirin Acuprin® An increase in nitroglycerin concentrations and additive platelet function depression Details Nitroglycerin Sublingual Dihydroergotamine Brekiya Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Nitroglycerin Sublingual Nitric Oxide An increased risk of methemoglobinemia Details Nitroglycerin Sublingual Pancuronium An increase in pancuronium duration of action Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.