Nitroglycerin Topical

15 interactions 500 cited references
Also sold as: Nitro-Bid Nitro-Bid® Ointment Rectiv®
About Nitroglycerin Topical

Nitroglycerin ointment (Nitro-Bid) is used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Nitroglycerin ointment can only be used to prevent attacks of angina; it cannot be used to treat an attack of angina once it h… Read the full Nitroglycerin Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Avanafil Riociguat Sildenafil Tadalafil Vardenafil Alteplase, Recombinant
5 Contraindicated 4 Major 6 Moderate
All (15) Contraindicated (5) Major (4) Moderate (6)

Contraindicated

Nitroglycerin Topical Avanafil Stendra Potentiation of hypotensive effects Details Nitroglycerin Topical Riociguat Adempas Increased risk of hypotension Details Nitroglycerin Topical Sildenafil Liqrev Potentiation of hypotensive effects Details Nitroglycerin Topical Tadalafil Adcirca Increased hypotensive effects of nitrates Details Nitroglycerin Topical Vardenafil Levitra Potentiation of hypotensive effects Details

Major

Nitroglycerin Topical Alteplase, Recombinant Activase Less coronary artery reperfusion, longer time to reperfusion, and more coronary artery reocclusion Details Nitroglycerin Topical Articaine An increased risk of methemoglobinemia Details Nitroglycerin Topical Heparin A decrease in partial thromboplastin time Details Nitroglycerin Topical Lidocaine Akten An increased risk of methemoglobinemia Details

Moderate

Nitroglycerin Topical Acetylcysteine Acetadote Enhanced hypotension and nitroglycerin-induced headache Details Nitroglycerin Topical Apomorphine Apokyn An increased risk of hypotension Details Nitroglycerin Topical Aspirin Acuprin® An increase in nitroglycerin concentrations and additive platelet function depression Details Nitroglycerin Topical Dihydroergotamine Brekiya Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Nitroglycerin Topical Nitric Oxide An increased risk of methemoglobinemia Details Nitroglycerin Topical Pancuronium An increase in pancuronium duration of action Details

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