Nitrous Oxide

22 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Esketamine Nasal Spray Nalbuphine Injection Metoclopramide Nasal Spray Cetirizine Injection Levodopa Oral Inhalation
20 Major 2 Moderate
All (22) Major (20) Moderate (2)

Major

Nitrous Oxide Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Nitrous Oxide Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Nitrous Oxide Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Nitrous Oxide Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Nitrous Oxide Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Nitrous Oxide Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Nitrous Oxide Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Nitrous Oxide Diazepam Rectal Diastat Increased risk of CNS depression Details Nitrous Oxide Esketamine Nasal Spray Spravato Increased risk of sedation Details Nitrous Oxide Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death and an increased risk of cardiovascular d... Details Nitrous Oxide Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Nitrous Oxide Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Nitrous Oxide Lacosamide Injection Motpoly An increased risk of CNS depression Details Nitrous Oxide Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Nitrous Oxide Methotrexate Jylamvo An increased risk of methotrexate toxicity Details Nitrous Oxide Methotrexate Injection Abitrexate® An increased risk of methotrexate toxicity Details Nitrous Oxide Metoclopramide Injection Gimoti Increased risk of CNS depression Details Nitrous Oxide Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Nitrous Oxide Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Nitrous Oxide Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Nitrous Oxide Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Nitrous Oxide Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.