Nizatidine

Name: Nizatidine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

48 interactions 190 cited references

Also sold as: Axid® Axid® AR

About Nizatidine

Nizatidine is used to treat and prevent the recurrence of ulcers and to treat other conditions where the stomach makes too much acid. Nizatidine also is used to treat or prevent occasional heartburn, acid indigestion, or sour stomach. It decreases the amount of acid made in the stomach. Nizatidine is available with and… Read the full Nizatidine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Cefuroxime Neratinib Erlotinib Gefitinib Infigratinib

33 Major 11 Moderate 4 Minor

All (48) Major (33) Moderate (11) Minor (4)

Moderate

Nizatidine Fosamprenavir Lexiva Decreased amprenavir serum concentrations (active metabolite of fosamprenavir) and potential reduction of amprenavir efficacy Details Nizatidine Itraconazole Sporanox Reduced itraconazole exposure Details Nizatidine Risedronate Actonel Increased bioavailability of risedronate Details Nizatidine Velpatasvir Decreased velpatasvir exposure Details

Minor

Nizatidine Bisacodyl Alophen Reformulated Jan 2008 Decreased effectiveness of bisacodyl Details Nizatidine Bisacodyl Rectal Bisac-Evac Decreased effectiveness of bisacodyl Details Nizatidine Ceftibuten Cedax® An increased risk of ceftibuten adverse effects Details Nizatidine Ponatinib Iclusig Decreased ponatinib efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.