Nizatidine

48 interactions 190 cited references
Also sold as: Axid® Axid® AR
About Nizatidine

Nizatidine is used to treat and prevent the recurrence of ulcers and to treat other conditions where the stomach makes too much acid. Nizatidine also is used to treat or prevent occasional heartburn, acid indigestion, or sour stomach. It decreases the amount of acid made in the stomach. Nizatidine is available with and… Read the full Nizatidine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Injection Cefuroxime Neratinib Erlotinib Gefitinib Infigratinib
33 Major 11 Moderate 4 Minor
All (48) Major (33) Moderate (11) Minor (4)

Major

Nizatidine Acalabrutinib Calquence Reduced acalabrutinib exposure Details Nizatidine Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Nizatidine Dasatinib Phyrago Reduced dasatinib exposure Details Nizatidine Erlotinib Tarceva Reduced erlotinib exposure Details Nizatidine Gefitinib Iressa Decreased exposure of gefitinib Details Nizatidine Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Nizatidine Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Nizatidine Methylphenidate Adhansia XR® Altered pharmacodynamic and changes in release profile of methylphenidate Details Nizatidine Methylphenidate Transdermal Patch Daytrana Altered pharmacodynamic and changes in release profile of methylphenidate Details Nizatidine Neratinib Nerlynx Decreased neratinib solubility, absorption, and exposure Details Nizatidine Atazanavir Reyataz Reduced atazanavir exposure Details Nizatidine Cefuroxime Axetil Decreased cefuroxime axetil exposure Details Nizatidine Defactinib Reduced defactinib exposure and an reduced efficacy of defactinib Details Nizatidine Delavirdine Rescriptor® Reduced serum delavirdine levels Details Nizatidine Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased rick of phenytoin or fosphenytoin toxicity Details Nizatidine Ketoconazole Extina Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Nizatidine Ledipasvir Decreased ledipasvir exposure and loss of efficacy Details Nizatidine Levoketoconazole Recorlev Reduced levoketoconazole exposure Details Nizatidine Nilotinib Reduced nilotinib exposure Details Nizatidine Nirogacestat Ogsiveo Reduced nirogacestat exposure and reduced efficacy of nirogacestat Details Nizatidine Octreotide Bynfezia Decreased octreotide bioavailability Details Nizatidine Pazopanib Votrient Decreased pazopanib bioavailability Details Nizatidine Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased rick of phenytoin or fosphenytoin toxicity Details Nizatidine Rilpivirine Edurant Reduced rilpivirine exposure Details Nizatidine Rilzabrutinib Wayrilz Reduced rilzabrutinib exposure and reduced efficacy of rilzabrutinib Details Nizatidine Secretin Human Chirhostim False positive secretin stimulation test results Details Nizatidine Selpercatinib Retevmo Reduced selpercatinib exposure and reduced anti-tumor activity Details Nizatidine Sotorasib Lumakras Reduced sotorasib exposure and anti-tumor activity Details Nizatidine Sparsentan Filspari Reduced sparsentan exposure and reduced efficacy of sparsentan Details Nizatidine Taletrectinib Ibtrozi Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Nizatidine Vismodegib Erivedge Reduced vismodegib systemic exposure Details Nizatidine Ziftomenib Komzifti Reduced ziftomenib exposure and reduced efficacy of ziftomenib Details Nizatidine Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Nizatidine Bosutinib Bosulif Reduced bosutinib exposure Details Nizatidine Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Nizatidine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Nizatidine Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Nizatidine Amprenavir Decreased amprenavir serum concentrations (active metabolite of fosamprenavir) and potential reduction of amprenavir efficacy Details Nizatidine Cefditoren Pivoxil Decreased cefditoren serum concentrations Details Nizatidine Cefpodoxime Proxetil Decreased cefpodoxime effectiveness Details

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