Nomegestrol

45 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Penicillin G Procaine Injection Colesevelam Cefprozil Meropenem Injection Bexarotene Topical
39 Major 6 Moderate
All (45) Major (39) Moderate (6)

Major

Nomegestrol Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Nomegestrol Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Nomegestrol Ampicillin Amcill® Decreased contraceptive effectiveness Details Nomegestrol Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Nomegestrol Bexarotene Targretin Decreased contraceptive effectiveness Details Nomegestrol Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Nomegestrol Cefaclor Ceclor® Decreased contraceptive effectiveness Details Nomegestrol Cefadroxil Duricef® Decreased contraceptive effectiveness Details Nomegestrol Cefdinir Omnicef® Decreased contraceptive effectiveness Details Nomegestrol Cefixime Suprax Decreased contraceptive effectiveness Details Nomegestrol Cefprozil Cefzil® Decreased contraceptive effectiveness Details Nomegestrol Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Nomegestrol Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Nomegestrol Colesevelam Welchol Decreased contraceptive effectiveness Details Nomegestrol Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Nomegestrol Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Nomegestrol Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Nomegestrol Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Nomegestrol Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Nomegestrol Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Nomegestrol Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Nomegestrol Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Nomegestrol Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Nomegestrol Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Nomegestrol Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Nomegestrol Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Nomegestrol Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Nomegestrol Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Nomegestrol Methylergonovine Methergine Increased methylergonovine exposure Details Nomegestrol Minocycline Amzeeq Decreased contraceptive efficacy Details Nomegestrol Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Nomegestrol Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Nomegestrol Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nomegestrol Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Nomegestrol Nifedipine Adalat® Increased NIFEdipine exposure Details Nomegestrol Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Nomegestrol Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Nomegestrol Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details Nomegestrol Penicillin V Potassium Beepen-VK® Decreased contraceptive effectiveness Details

Moderate

Nomegestrol Amitriptyline Elavil Explained Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details

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