Norelgestromin

18 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mitapivat Meropenem Meropenem Injection Methylergonovine Nevirapine Nifedipine
16 Major 2 Moderate
All (18) Major (16) Moderate (2)

Major

Norelgestromin Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Norelgestromin Bexarotene Targretin Decreased contraceptive effectiveness Details Norelgestromin Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Norelgestromin Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norelgestromin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norelgestromin Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Norelgestromin Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Norelgestromin Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Norelgestromin Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Norelgestromin Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norelgestromin Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norelgestromin Methylergonovine Methergine Increased methylergonovine exposure Details Norelgestromin Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Norelgestromin Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Norelgestromin Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Norelgestromin Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Norelgestromin Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Norelgestromin Dofetilide Tikosyn Increased dofetilide exposure Details

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