Norgestimate

52 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Penicillin G Procaine Injection Colesevelam Cefprozil Meropenem Injection Bexarotene Topical

41 Major 11 Moderate

All (52) Major (41) Moderate (11)

Major

Norgestimate Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Norgestimate Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Norgestimate Ampicillin Amcill® Decreased contraceptive effectiveness Details Norgestimate Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Norgestimate Bexarotene Targretin Decreased contraceptive effectiveness Details Norgestimate Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Norgestimate Cefaclor Ceclor® Decreased contraceptive effectiveness Details Norgestimate Cefadroxil Duricef® Decreased contraceptive effectiveness Details Norgestimate Cefdinir Omnicef® Decreased contraceptive effectiveness Details Norgestimate Cefixime Suprax Decreased contraceptive effectiveness Details Norgestimate Cefprozil Cefzil® Decreased contraceptive effectiveness Details Norgestimate Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Norgestimate Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Norgestimate Colesevelam Welchol Decreased contraceptive effectiveness Details Norgestimate Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Norgestimate Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Norgestimate Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norgestimate Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Norgestimate Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Norgestimate Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Norgestimate Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Norgestimate Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Norgestimate Felbamate Felbatol Reduced norgestimate/ethinyl estradiol exposure and an increased risk of breakthrough bleeding/contraceptive failure Details Norgestimate Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Norgestimate Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Norgestimate Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Norgestimate Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Norgestimate Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Norgestimate Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norgestimate Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Norgestimate Methylergonovine Methergine Increased methylergonovine exposure Details Norgestimate Minocycline Amzeeq Decreased contraceptive efficacy Details Norgestimate Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Norgestimate Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Norgestimate Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Norgestimate Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Norgestimate Nifedipine Adalat® Increased NIFEdipine exposure Details Norgestimate Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Norgestimate Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Norgestimate Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details

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