Drug Interaction Report

Octreotide and Rosiglitazone: Interaction Details

A pharmacist-reviewed analysis of the Octreotide and Rosiglitazone interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Octreotide

Bynfezia Mycapssa Mycapssa® Sandostatin
+

Rosiglitazone

Avandia®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 380 documented Octreotide interactions, 363 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of hypoglycemia and impaired glucose regulation

Interaction Deep Dive

Somatostatin analogs inhibit the secretion of insulin and glucagon1. Severe increases in blood glucose levels may occur. Optimize antidiabetic treatment in patients with poorly-controlled diabetes prior to starting the somatostatin analog 2. Dose adjustment of the antidiabetic agent and increased frequency of glucose monitoring may be necessary 345.

Why it happens (mechanism)

Altered glucose metabolism

Common questions

Can I take Octreotide and Rosiglitazone together?

An increased risk of hypoglycemia and impaired glucose regulation Always confirm with your pharmacist or prescriber before making any change.

How serious is the Octreotide and Rosiglitazone interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Octreotide or Rosiglitazone need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (5)

  1. Product Information: Sandostatin(R) LAR Depot intramuscular injection suspension, octreotide acetate intramuscular injection suspension. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2014.
  2. Product Information: SIGNIFOR(R) LAR intramuscular injection suspension, pasireotide intramuscular injection suspension. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2014.
  3. Product Information: TOUJEO(R) subcutaneous injection, insulin glargine subcutaneous injection. sanofi-aventis (per manufacturer), Bridgewater, NJ, 2015. DailyMed
  4. Product Information: Tresiba subcutaneous injection solution, insulin degludec subcutaneous injection solution. Novo Nordisk A/S (per EMA), Bagsvaerd, Denmark, 2013. DailyMed
  5. Product Information: ADMELOG(R) subcutaneous, intravenous injection, insulin lispro subcutaneous, intravenous injection. sanofi-aventis US LLC (per DailyMed), Bridgewater, NJ, 2023. DailyMed
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Octreotide

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All Octreotide interactions (380) Octreotide drug information
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Rosiglitazone

Keep reading about Rosiglitazone

All Rosiglitazone interactions (45) Rosiglitazone drug information
Also serious with: Moxifloxacin Chloroquine Insulin Glulisine (Rdna Origin) Injection Ofloxacin Otic
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Octreotide + Activated Charcoal Adrafinil Cannabidiol (cbd) Cannabinol (cbn) Cannabis Coffee Charcoal Delta-9-tetrahydrocannabinol (thc) Ergot + 22 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.