Rosiglitazone and Chloroquine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Chloroquine
Rosiglitazone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hypoglycemia
Interaction Deep Dive
Chloroquine may enhance the effects of hypoglycemic treatment, a decrease in doses of insulin or other antidiabetic drugs may be required21.
Why it happens (mechanism)
Additive hypoglycemic affects
Common questions
Can I take Rosiglitazone and Chloroquine together?
Hypoglycemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Rosiglitazone and Chloroquine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Rosiglitazone or Chloroquine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Chloroquine phosphate oral tablets, chloroquine phosphate oral tablets. Rising Pharmaceuticals Inc (per DailyMed), Saddle Brook, NJ, 2018. DailyMed
- US Food & Drug Administration (FDA): Fact sheet for health care providers emergency use authorization (EUA) of chloroquine phosphate supplied from the strategic national stockpile for treatment of COVID-19 in certain hospitalized patients. US Food & Drug Administration (FDA). Silver Spring, MD. 2020.
Keep reading about Chloroquine
Keep reading about Rosiglitazone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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