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Chloroquine

Chloroquine is an antimalarial (anti-protozoal) medicine used to treat and prevent certain types of malaria and to treat amebiasis that has spread outside the intestine.

Brand name Aralen
Drug class Antimalarial
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 6 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 8, 2026
Chloroquine at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Chloroquine (Aralen) is an older antimalarial, on the U.S. market since about 1949 and available as a generic, that treats and prevents malaria where the parasite is not resistant and treats amebiasis outside the intestine; it seems to build up inside the parasite and block how it processes heme from blood. Short courses are usually well tolerated, and stomach upset (nausea, cramps, diarrhea), a mild headache and itching are the usual complaints. The real risks are to the eyes, heart, blood sugar and mood, so report blurred vision, a racing or irregular heartbeat, shakiness and sweating, or mood changes right away.

Clinical pearls

  • For prevention, take it on the same weekday every week, starting before the trip and continuing after you leave the malaria area.
  • Keep antacids and kaolin at least 4 hours apart from chloroquine, since they cut how much of it gets absorbed.
  • If you use insulin or other diabetes medicines, watch closely for low blood sugar, because those doses may need lowering.
  • Lock the tablets away from children, who are very sensitive to chloroquine; an accidental swallow can be fatal.
How you get itPrescription only
Comes asTablet
Earliest FDA record1949
Companies listing it with the FDA5
FDA label last updatedNov 7, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Chloroquine, written from its FDA label.

What Chloroquine is used for

▾

Chloroquine is used for several parasite infections.

  • Chloroquine phosphate tablets treat uncomplicated malaria due to susceptible P. falciparum, P. malariae, P. ovale and P. vivax.
  • Chloroquine phosphate tablets prevent malaria in areas where chloroquine resistance is not present.
  • Chloroquine phosphate tablets treat extraintestinal amebiasis.
  • It does not prevent relapses of vivax or ovale malaria and should not be used for complicated malaria such as cerebral malaria or acute kidney failure.

How Chloroquine works

▾

Chloroquine is an anti-protozoal that builds up in the acid compartments of the malaria parasite and blocks heme polymerization (the parasite’s way of handling a part of blood). It may also interfere with certain enzymes through its interaction with DNA. The exact mechanism is not fully known.

It works against the blood stages of susceptible malaria parasites, but not the liver-stage forms of P. vivax and P. ovale. Resistance is widespread, especially in P. falciparum.

Chloroquine dosage

▾

Chloroquine phosphate tablets are taken by mouth. Doses are often described as chloroquine base, and children’s doses are calculated by body weight.

  • Prevention: once a week on exactly the same day, starting two weeks before exposure if possible, and continuing for eight weeks after leaving the area.
  • Malaria treatment: several doses spread over about three days.
  • Amebiasis: daily for at least two to three weeks, usually with another medicine that works in the intestine.

Follow your prescriber and the label for your exact schedule.

Dosing details from the FDA-approved label

From the Chloroquine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Prophylaxis against chloroquine-sensitive Plasmodium species - Adult
    • 500 mg (= 300 mg base) administered once per week on exactly the same day of each week
    • If circumstances permit, begin suppressive therapy two weeks prior to exposure
    • Failing this, an initial double (loading) dose of 1 g (= 600 mg base) may be taken in two divided doses, six hours apart
    • Continue for eight weeks after leaving the endemic area
  • Prophylaxis against chloroquine-sensitive Plasmodium species - Pediatric
    • 5 mg calculated as base, per kg of body weight, administered once per week on exactly the same day of each week
    • If failing to start two weeks prior to exposure, an initial loading dose of 10 mg base/kg may be taken in two divided doses, six hours apart
    • Continue for eight weeks after leaving the endemic area
    • Maximum: The pediatric dose should never exceed the adult dose regardless of weight
    • Dosage calculated by body weight
  • Treatment of uncomplicated malaria due to chloroquine-sensitive Plasmodium species - Adults
    • An initial dose of 1 g salt (= 600 mg base) followed by an additional 500 mg (= 300 mg base) after six to eight hours and a single dose of 500 mg (= 300 mg base) on each of two consecutive days
    • Maximum: Total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days
    • For P. vivax and P. ovale, concomitant therapy with an 8-aminoquinoline compound is necessary for the hypnozoite liver stage forms
  • Treatment of uncomplicated malaria due to chloroquine-sensitive Plasmodium species - Infants and Children
    • 10 mg base/kg followed by 5 mg base/kg at 6, 24 and 36 hours (total dose 25 mg base/kg)
    • Maximum: First dose not exceeding a single dose of 600 mg base; second dose not exceeding a single dose of 300 mg base; pediatric dose should never exceed the adult dose regardless of weight
    • Same weight-based schedule applies to adults of low body weight; dosing by body weight
  • Extraintestinal amebiasis - Adults
    • 1 g salt (600 mg base) daily for two days, followed by 500 mg (300 mg base) daily for at least two to three weeks
    • Usually combined with an effective intestinal amebicide
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 250 mg and 500 mg tablet of chloroquine phosphate tablet contains the equivalent of 150 mg and 300 mg chloroquine base respectively. In infants and children the dosage is preferably calculated by body weight. Prophylaxis against chloroquine-sensitive Plasmodium species Adult Dose: The dosage for prophylaxis is 500 mg (= 300 mg base) administered once per week on exactly the same day of each week. Pediatric Dose: The dosage for prophylaxis is 5 mg calculated as base, per kg of body weight, administered once per week on exactly the same day of each week. The pediatric dose should never exceed the adult dose regardless of weight. If circumstances permit, suppressive therapy should begin two weeks prior to exposure. However, failing this in adults, an initial double (loading) dose of 1 g (= 600 mg base), or in children 10 mg base/kg may be taken in two divided doses, six hours apart. The suppressive therapy should be continued for eight weeks after leaving the endemic area. Treatment of uncomplicated malaria due to chloroquine-sensitive Plasmodium species Adults: An initial dose of 1 g salt (= 600 mg base) followed by an additional 500 mg (= 300 mg base) after six to eight hours and a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. Infants and Children: In infants and children, the recommended dose is 10 mg base/kg followed by 5 mg based/kg at 6, 24 and 36 hours (total dose 25 mg based/kg). The pediatric dose should never exceed the adult dose regardless of weight. The dosage for adults of low body weight and for infants and children should be determined as follows: First dose: 10 mg base per kg (but not exceeding a single dose of 600 mg base). Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding a single dose of 300 mg base). Third dose: (24 hours after first dose) 5 mg base per kg. Fourth dose: (36 hours after first dose) 5 mg base per kg. P. vivax and P. ovale: Concomitant therapy with an 8-aminoquinoline compound is necessary for treatment of the hypnozoite liver stage forms of the parasites.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Chloroquine side effects

▾

Common effects mostly involve the stomach and head.

Common side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal cramps
  • Loss of appetite
  • Mild, short-lived headache
  • Itching
  • Mild, temporary headache

When to get medical help

  • Vision changes, blurred vision, trouble reading, or missing parts of your vision (possible permanent retinal damage)
  • Fast, irregular or pounding heartbeat, fainting, or new shortness of breath (possible heart rhythm problems or heart muscle damage)
  • Shakiness, sweating, confusion or passing out (possible severe low blood sugar)
  • Depression, suicidal thoughts, mood changes, hallucinations or unusual behavior
  • Muscle weakness or numbness and tingling
  • Severe rash, blistering or peeling skin, or swelling of the face or throat
  • Fatigue, nausea, dark urine or yellow skin or eyes (possible liver problems)
  • Ringing in the ears or hearing loss

Call your doctor about vision changes, heart palpitations or fainting, signs of low blood sugar, mood changes, muscle weakness, severe rash, or yellow skin or eyes.

Chloroquine warnings and precautions

▾
  • Heart: cardiomyopathy (heart muscle disease) and rhythm problems, some fatal, especially at high doses.
  • Low blood sugar: can be severe, even if you do not take diabetes medicine.
  • Eyes: irreversible retinal damage is possible. Eye exams are recommended.
  • Mood: suicidal thoughts and neuropsychiatric changes, usually in the first month.
  • Muscles, nerves and kidneys: weakness, nerve problems and kidney injury can occur.
  • Skin and liver: may worsen psoriasis and porphyria, and has caused liver injury in people with porphyria cutanea tarda.
  • Children: accidental ingestion has caused deaths.

Chloroquine interactions

▾

Several medicines can change how chloroquine works or raise its risks.

  • Antacids and kaolin: lower absorption, so separate by at least 4 hours.
  • Cimetidine: raises chloroquine levels, so avoid.
  • Insulin and diabetes medicines: low blood sugar risk, so doses may need lowering.
  • Amiodarone, moxifloxacin and other QT-prolonging drugs: more risk of heart rhythm problems.
  • Ampicillin: lowered absorption, so separate by at least 2 hours.
  • Cyclosporine: levels may rise suddenly.
  • Mefloquine: higher seizure risk.
  • Tamoxifen: both can harm the retina, so not recommended together.
  • Praziquantel and rabies vaccine: effects may be reduced.

Interactions listed in the FDA-approved label

From the Chloroquine prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Antacids and kaolin: Can reduce absorption of chloroquine. Observe an interval of at least 4 hours between intake of these agents and chloroquine.
  • Cimetidine: Can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided.
  • Insulin and other antidiabetic drugs: Chloroquine may enhance the effects of a hypoglycemic treatment. A decrease in doses of insulin or other antidiabetic drugs may be required.
  • Arrhythmogenic drugs (such as amiodarone or moxifloxacin): There may be an increased risk of inducing ventricular arrhythmias.
  • Ampicillin: In healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. Observe an interval of at least two hours between intake of ampicillin and chloroquine.
  • Cyclosporine: A sudden increase in serum cyclosporine level has been reported after introduction of oral chloroquine. Close monitoring of serum cyclosporine level is recommended and, if necessary, chloroquine should be discontinued.
  • Mefloquine: Co-administration may increase the risk of convulsions.
  • Intradermal human diploid-cell rabies vaccine: Chloroquine taken in the dose recommended for malaria prophylaxis can reduce the antibody response to primary immunization.
  • Praziquantel: In a single-dose interaction study, chloroquine has been reported to reduce the bioavailability of praziquantel.
  • Tamoxifen: Tamoxifen is a drug known to induce retinal toxicity. Concomitant use of chloroquine with such drugs is not recommended.
Read the label’s full interactions text

Drug Interactions Antacids and kaolin: Antacids and kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed. Cimetidine: Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided. Insulin and other antidiabetic drugs: As chloroquine may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or other antidiabetic drugs may be required. Arrhythmogenic drugs: There may be an increased risk of inducing ventricular arrhythmias if chloroquine is used concomitantly with other arrhythmogenic drugs, such as amiodarone or moxifloxacin. Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of ampicillin and chloroquine should be observed. Cyclosporine: After introduction of chloroquine (oral form), a sudden increase in serum cyclosporine level has been reported. Therefore, close monitoring of serum cyclosporine level is recommended and, if necessary, chloroquine should be discontinued. Mefloquine: Co-administration of chloroquine and mefloquine may increase the risk of convulsions. The blood concentrations of chloroquine and desethylchloroquine (the major metabolite of chloroquine, which also has antimalarial properties) were negatively associated with log antibody titers. Chloroquine taken in the dose recommended for malaria prophylaxis can reduce the antibody response to primary immunization with intradermal human diploid-cell rabies vaccine. Praziquantel: In a single-dose interaction study, chloroquine has been reported to reduce the bioavailability of praziquantel. Tamoxifen: Concomitant use of chloroquine with drugs known to induce retinal toxicity such as tamoxifen is not recommended (see WARNINGS ).

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Before taking Chloroquine

▾
  • Do not use it if you have had an allergy to 4-aminoquinoline medicines.
  • Tell your doctor about retinal or visual field changes.
  • Tell your doctor about heart disease, rhythm problems, slow heartbeat, or low potassium or magnesium.
  • Mention psoriasis, porphyria, G6PD deficiency, kidney or liver issues, or diabetes.
  • In pregnancy, your doctor should review the benefits and risks first.
  • Children’s doses are weight-based and must never exceed the adult dose. Store tablets safely away from kids.

Chloroquine overdose

▾

Chloroquine overdose is a life-threatening emergency, and as little as 1 g may be fatal in children. Symptoms can start within minutes and include nausea, vomiting, headache, drowsiness, vision problems, seizures and dangerous heart rhythms. Get immediate emergency medical help.

What Chloroquine does in the body

▾

Chloroquine is active against the blood stages of susceptible malaria parasites and against amoeba forms called trophozoites. It is not active against gametocytes or the liver-stage forms of P. vivax and P. ovale. It can lengthen the QT interval, and this effect increased when it was combined with azithromycin in a study.

How your body processes Chloroquine

▾

Chloroquine is rapidly and almost completely absorbed from the gut. About 55% is bound to proteins in the blood, and it collects heavily in tissues such as the liver, spleen, kidney and lung. The body breaks it down partly into desethylchloroquine. It is cleared slowly, and this is faster when the urine is acidic.

How to store Chloroquine

▾

Dispense in tight, light-resistant container as defined in the USP. Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F)

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

29

Supplements & herbs that interact with Chloroquine

29 supplements and herbal products have documented interactions with Chloroquine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 2
  • Moderate · 18
  • Minor · 9
Every supplement checked against Chloroquine — ranked by severity The full interaction hub: 2 major · 18 moderate · 9 minor · every one linked to its full report. Check Chloroquine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Chloroquine: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Chloroquine — the kind of thing our pharmacy team would talk through with you at the counter.

What is chloroquine for?

▾
It treats uncomplicated malaria and helps prevent malaria in areas where the parasite is still sensitive to it. It is also used for amebiasis outside the intestine. It will not work in areas with chloroquine-resistant malaria, so check your travel region with your doctor or the CDC.

How do I take it for malaria prevention?

▾
You take it by mouth once a week on exactly the same day each week. It is usually started before travel and continued for eight weeks after you leave the area. Follow your prescriber’s schedule and set a reminder so you do not miss a week.

What side effects should I expect?

▾
The most common ones are an upset stomach, nausea, vomiting, diarrhea, cramps, a mild headache and itching. These are often manageable. Call your doctor right away for vision changes, a racing or irregular heartbeat, fainting, mood changes, shakiness or confusion from low blood sugar, or a severe rash.

Does it affect my eyes?

▾
It can cause permanent retinal damage, mainly with higher doses, long use, kidney problems, tamoxifen use, or existing macular disease. A baseline eye exam is recommended in the first year. Tell your doctor about any change in vision.

Can I take antacids or other medicines with it?

▾
Keep antacids at least 4 hours apart from chloroquine, and ampicillin at least 2 hours apart. Avoid cimetidine, and tell me about diabetes medicines, heart rhythm drugs, tamoxifen, cyclosporine or mefloquine. Always check with me before starting anything new.

Is it safe around children and in pregnancy?

▾
Keep it locked away from children, because even small amounts have caused deaths. In pregnancy, studies at usual malaria doses showed no increase in birth defects or miscarriage. Your doctor should still weigh the benefits and risks for you.

Is Chloroquine available over the counter?

▾
No. Chloroquine is a prescription medicine: every Chloroquine product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Chloroquine first available?

▾
The earliest FDA record we hold for Chloroquine is from 1949: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Chloroquine was first used.

Who makes Chloroquine?

▾
5 companies currently list Chloroquine products in the FDA's NDC Directory, including Amneal Pharmaceuticals of New York LLC, Rising Pharma Holdings, Inc., AvKARE. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Chloroquine on HelloPharmacist

Detailed data & references for Chloroquine Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Chloroquine forms and strengths (how it comes)

Chloroquine is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Chloroquine inactive ingredients by manufacturer.

Tablet

By mouth
How this form is used
What it may be used for
  • Chloroquine Phosphate tablets treat uncomplicated malaria from susceptible parasites.
  • Chloroquine Phosphate tablets prevent malaria in areas without chloroquine resistance.
  • Chloroquine Phosphate tablets treat extraintestinal amebiasis.
Important instructions
  • Chloroquine Phosphate tablets are taken by mouth.
  • For malaria prevention, Chloroquine Phosphate tablets are taken once a week on the same day each week.
  • Chloroquine Phosphate doses for children are based on body weight and should never exceed the adult dose.
Available strengths 2 strengths
18 FDA-listed product records ⓘ

Chloroquine on the U.S. market: products, makers and brands

How Chloroquine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

5 companies list 7 Chloroquine product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1949. Brand names on the directory include Aralen; the rest are generics.

1
Dose forms ⓘ
5
Labelers (makers, repackagers, distributors)
1
Brand names
7
FDA-listed product records ⓘ
1949
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Amneal Pharmaceuticals of New York LLC29%
Rising Pharma Holdings, Inc.29%
AvKARE14%
Avet Pharmaceuticals Inc.14%
Chartwell RX, LLC14%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Chloroquine is used (Medicaid data)

A general measure of how commonly Chloroquine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Chloroquine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

370
Medicaid prescriptions filled (Q1–Q4 2025)
$33,153 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Chloroquine prescribed? Of the 1,601 medications we measure, Chloroquine ranks #1,394 by Medicaid prescriptions — more than 13% of them.

Where Chloroquine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Chloroquine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 250 mg oral tablet is the most-dispensed Chloroquine product — about 96% of these Medicaid prescriptions.

chloroquine phosphate 250 MG Oral Tablet Most dispensed

357 Medicaid prescriptions (Q1–Q4 2025) 96% of Chloroquine prescriptions shown $32,304 gross reimbursement (before rebates) ≈ $90 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1117531

chloroquine phosphate 500 MG Oral Tablet

13 Medicaid prescriptions (Q1–Q4 2025) 4% of Chloroquine prescriptions shown $849 gross reimbursement (before rebates) ≈ $65 per prescription (gross)

Summed across the 1 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1116758

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Chloroquine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 3 of 23 listed Chloroquine NDCs with Medicaid activity.

Compare Chloroquine products

A representative set of FDA-listed product records for Chloroquine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Tablet
250 mg Oral Amneal Pharmaceuticals of New York LLC ANDA View NDC →
500 mg Oral Amneal Pharmaceuticals of New York LLC ANDA View NDC →
500 mg Oral Avet Pharmaceuticals Inc. ANDA View NDC →
500 mg Oral AvKARE ANDA View NDC →
500 mg Oral Chartwell RX, LLC ANDA View NDC →
250 mg Oral Rising Pharma Holdings, Inc. ANDA View NDC →
500 mg Oral Rising Pharma Holdings, Inc. ANDA View NDC →

Showing 7 of 7 products — FDA National Drug Code Directory. See every product, package size and price: browse all 7 Chloroquine NDCs →

Chloroquine recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Chloroquine recalls since July 2021.

✅No Chloroquine recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Oct 8, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Chloroquine RxCUI 2393 2 dose forms · 5 strengths
  1. Dose form (SCDF) Oral Solution RxCUI 756408 No current FDA listing
    Clinical drug / strength (SCD) phosphate 16 MG/ML RxCUI 1117346 sulfate 13.6 MG/ML RxCUI 1117351
  2. Dose form (SCDF) Oral Tablet RxCUI 371407 In current FDA listings
    Clinical drug / strength (SCD) phosphate 250 MG RxCUI 1117531 phosphate 500 MG RxCUI 1116758 sulfate 200 MG RxCUI 1117353

Look up RxCUI 2393 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Chloroquine costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet · Oral 500 mg $6.65 per tablet NDC details & price history
Tablet · Oral 250 mg $2.54 per tablet NDC details & price history
Tablet, Coated · Oral 500 mg $6.65 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Chloroquine brand names

Chloroquine is sold under one brand name in the FDA directory — Aralen. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Aralen

Who makes Chloroquine: manufacturers and labelers

5 companies list Chloroquine products with the FDA. By number of product records, the largest are Amneal Pharmaceuticals of New York LLC, Rising Pharma Holdings, Inc., AvKARE. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Amneal Pharmaceuticals of New York LLC 2 Rising Pharma Holdings, Inc. 2 AvKARE 1 Avet Pharmaceuticals Inc. 1 Chartwell RX, LLC 1

Chloroquine drug class (RxNorm)

Chloroquine belongs to the Antimalarial class.

Pharmacologic class Antimalarial
Drug family (ATC) Biguanides, Aminoquinolines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Chloroquine page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 7, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Chloroquine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Chloroquine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
6
Finished products in the current FDA directory
7
Companies listing them (makers, repackagers, distributors)
5
FDA labeler codes behind them ⓘ
5
Linked representative label ⓘ
Avet Pharmaceuticals Inc.
Linked label effective
Nov 7, 2025
Composite sections available
17
Linked SPL Set ID
f4ac1556-0522-76e3-e053-2a95a90a5ba8
Linked SPL Document ID
ff449b60-19d4-41e8-903c-68bc56fc23e0
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Avet Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →