Ofatumumab Injection (Multiple Sclerosis)

15 interactions 265 cited references
Also sold as: Arzerra Kesimpta Kesimpta®
About Ofatumumab Injection (Multiple Sclerosis)

Ofatumumab injection is used to prevent episodes of symptoms and slow the worsening of disability in adults who have relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, spee… Read the full Ofatumumab Injection (Multiple Sclerosis) drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Measles Virus Vaccine, Live Varicella Virus Vaccine, Live
9 Contraindicated 6 Major
All (15) Contraindicated (9) Major (6)

Contraindicated

Ofatumumab Injection (Multiple Sclerosis) Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Ofatumumab Injection (Multiple Sclerosis) Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ofatumumab Injection (Multiple Sclerosis) Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.