Ofloxacin Ophthalmic

337 interactions 674 cited references
Also sold as: Ocuflox Ocuflox®
About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil
12 Contraindicated 240 Major 84 Moderate 1 Minor
All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Relugolix Orgovyx Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Repaglinide Prandin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Revumenib Revuforj An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ribociclib Kisqali An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Rosiglitazone Avandia® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Saxagliptin Onglyza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Selpercatinib Retevmo Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Semaglutide Ozempic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Sematilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Sertraline An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sevoflurane Petrem Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Siponimod Mayzent An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sitagliptin Brynovin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Sodium Phosphate OsmoPrep An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sodium Phosphate, Dibasic An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sodium Phosphate, Monobasic An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Solifenacin Vesicare An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sorafenib Nexavar An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sotalol Betapace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Sulpiride An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sunitinib Sutent An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Tacrolimus Astagraf An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Tamoxifen Nolvadex® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Tedisamil An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Telithromycin An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Tetrabenazine Xenazine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Tizanidine Increased tizanidine plasma concentrations Details Ofloxacin Ophthalmic Tolazamide Tolinase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Tolbutamide Orinase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Toremifene Fareston An increased risk of QT interval prolongation, ventricular tachycardia or an increased risk of torsade de pointes Details Ofloxacin Ophthalmic Tramadol ConZip An increased risk of seizure Details Ofloxacin Ophthalmic Trazodone Raldesy An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Ofloxacin Ophthalmic Triamcinolone Aller-Cort An increased risk of tendon rupture Details Ofloxacin Ophthalmic Triclabendazole Egaten An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Trifluoperazine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Trimipramine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Triptorelin Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Vandetanib Caprelsa Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.