Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Vardenafil Levitra An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Vemurafenib Zelboraf Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Venlafaxine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Ofloxacin Ophthalmic Vilanterol An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Vinflunine Increased risk of QT-interval prolongation Details Ofloxacin Ophthalmic Voclosporin Lupkynis An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Voglibose Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Voriconazole Vfend An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Warfarin Coumadin An increased risk of bleeding Details Ofloxacin Ophthalmic Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Zuclopenthixol An increased risk of QT interval prolongation Details

Moderate

Ofloxacin Ophthalmic Aceclofenac An increased risk of seizures Details Ofloxacin Ophthalmic Acemetacin An increased risk of seizures Details Ofloxacin Ophthalmic Aluminum Carbonate, Basic Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Aluminum Hydroxide AlternaGEL® Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Aluminum Phosphate Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Aminolevulinic Acid Increased risk of phototoxic skin reaction (ie, severe sunburn) Details Ofloxacin Ophthalmic Amtolmetin Guacil An increased risk of seizures Details Ofloxacin Ophthalmic Aspirin Acuprin® An increased risk of seizures Details Ofloxacin Ophthalmic Bromfenac Bromsite An increased risk of seizures Details Ofloxacin Ophthalmic Bufexamac An increased risk of seizures Details Ofloxacin Ophthalmic Calcium Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Celecoxib Celebrex An increased risk of seizures Details Ofloxacin Ophthalmic Choline Salicylate An increased risk of seizures Details Ofloxacin Ophthalmic Clonixin An increased risk of seizures Details Ofloxacin Ophthalmic Dandelion Decreased fluoroquinolone effectiveness Details Ofloxacin Ophthalmic Dexibuprofen An increased risk of seizures Details Ofloxacin Ophthalmic Dexketoprofen An increased risk of seizures Details Ofloxacin Ophthalmic Diclofenac Aleve Arthritis Pain An increased risk of seizures Details Ofloxacin Ophthalmic Didanosine Videx® Decreased ofloxacin bioavailability and potential loss of ofloxacin efficacy Details Ofloxacin Ophthalmic Diflunisal Dolobid An increased risk of seizures Details Ofloxacin Ophthalmic Dihydroxyaluminum Aminoacetate Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Dihydroxyaluminum Sodium Carbonate Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Dipyrone An increased risk of seizures Details Ofloxacin Ophthalmic Droxicam An increased risk of seizures Details Ofloxacin Ophthalmic Etodolac Lodine An increased risk of seizures Details Ofloxacin Ophthalmic Etofenamate An increased risk of seizures Details Ofloxacin Ophthalmic Etoricoxib An increased risk of seizures Details Ofloxacin Ophthalmic Felbinac An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.