Olopatadine

Name: Olopatadine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

7 interactions 42 cited references

Also sold as: Pataday PATANASE

Read the full Olopatadine drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydroxychloroquine Amifampridine Bupropion Clomipramine Donepezil Pitolisant

7 Major

All (7) Major (7)

Major

Olopatadine Hydroxychloroquine Plaquenil An increased risk of seizures Details Olopatadine Amifampridine Increased risk of seizures Details Olopatadine Bupropion Aplenzin Increased risk of seizures Details Olopatadine Clomipramine Anafranil Increased risk of seizures Details Olopatadine Donepezil Adlarity Reduced seizure threshold Details Olopatadine Pitolisant Wakix Reduced efficacy of pitolisant Details Olopatadine Tramadol ConZip An increased risk of seizure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.