Olsalazine

24 interactions
Also sold as: Dipentum Dipentum®
About Olsalazine

Olsalazine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults when another medication (sulfasalazine) could not be tolerated. Olsalazine is in a class of medications called anti-inflammatory agents. Olsalazine reduces the b… Read the full Olsalazine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nabumetone Fenoprofen Diclofenac Ophthalmic Diclofenac Topical (Actinic Keratosis) Naproxen Mefenamic Acid
20 Major 4 Moderate
All (24) Major (20) Moderate (4)

Major

Olsalazine Azathioprine Azasan An increased risk of bone marrow suppression, an increased risk of myelosuppression and an increased risk of hepatotoxicity Details Olsalazine Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Olsalazine Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Olsalazine Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Olsalazine Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Olsalazine Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Olsalazine Etodolac Lodine Increased risk of bleeding Details Olsalazine Fenoprofen Fenopron Increased risk of bleeding Details Olsalazine Flurbiprofen Ansaid Increased risk of bleeding Details Olsalazine Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Olsalazine Ketoprofen Actron® Increased risk of bleeding Details Olsalazine Meclofenamate Meclodium® Increased risk of bleeding Details Olsalazine Mefenamic Acid Ponstel® Increased risk of bleeding Details Olsalazine Mercaptopurine Purinethol® An increased risk of bone marrow suppression, an increased risk of myelosuppression and an increased risk of hepatotoxicity Details Olsalazine Mesalamine Apriso Increased risk of bleeding Details Olsalazine Mesalamine Rectal Canasa Increased risk of bleeding Details Olsalazine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Olsalazine Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Olsalazine Nabumetone Relafen Increased risk of bleeding Details Olsalazine Naproxen Aleve Increased risk of bleeding Details

Moderate

Olsalazine Furosemide Injection Disal An increased risk of salicylate toxicity Details Olsalazine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Olsalazine Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Olsalazine Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.