Omadacycline

60 interactions 25 cited references

Also sold as: Nuzyra Nuzyra®

About Omadacycline

Omadacycline is used to treat infections caused by bacteria, including pneumonia and certain infections of the skin. Omadacycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics such as omadacycline will not work for colds, flu, or othe… Read the full Omadacycline drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Argatroban Warfarin Acenocoumarol Bexarotene Topical

1 Contraindicated 42 Major 17 Moderate

All (60) Contraindicated (1) Major (42) Moderate (17)

Contraindicated

Omadacycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Omadacycline Isotretinoin Absorica An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Apixaban Eliquis Increased risk of bleeding Details Omadacycline Betrixaban Bevyxxa® Increased risk of bleeding Details Omadacycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Dabigatran Pradaxa® Increased risk of bleeding Details Omadacycline Dabigatran Etexilate Increased risk of bleeding Details Omadacycline Dalteparin Injection Fragmin Increased risk of bleeding Details Omadacycline Edoxaban Savaysa Increased risk of bleeding Details Omadacycline Enoxaparin Lovenox Increased risk of bleeding Details Omadacycline Enoxaparin Injection Lovenox Increased risk of bleeding Details Omadacycline Fondaparinux Arixtra Increased risk of bleeding Details Omadacycline Fondaparinux Injection Arixtra Increased risk of bleeding Details Omadacycline Heparin Increased risk of bleeding Details Omadacycline Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Omadacycline Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Omadacycline Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Omadacycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Omadacycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Omadacycline Acenocoumarol Increased risk of bleeding Details Omadacycline Ardeparin Increased risk of bleeding Details Omadacycline Argatroban Increased risk of bleeding Details Omadacycline Bivalirudin Angiomax Increased risk of bleeding Details Omadacycline Certoparin Increased risk of bleeding Details Omadacycline Dalteparin Fragmin Increased risk of bleeding Details Omadacycline Danaparoid Increased risk of bleeding Details Omadacycline Desirudin Iprivask Increased risk of bleeding Details Omadacycline Ethinyl Estradiol Reduced ethinyl estradiol exposure, reduced efficacy of ethinyl estradiol and an increased risk of breakthrough bleeding and/or co... Details Omadacycline Etretinate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Lepirudin Increased risk of bleeding Details Omadacycline Magnesium Sulfate May reduce absorption of tetracycline antibiotics Details Omadacycline Palovarotene Sohonos Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Omadacycline Parnaparin Increased risk of bleeding Details Omadacycline Phenindione Increased risk of bleeding Details Omadacycline Phenprocoumon Increased risk of bleeding Details Omadacycline Porfimer Excessive intracellular damage in photosensitized tissues Details Omadacycline Protein C Ceprotin Increased risk of bleeding Details Omadacycline Reviparin Increased risk of bleeding Details Omadacycline Rivaroxaban Xarelto Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.